Hampshire-Araújo Fabrício, Bergmann Anke, Alvarenga Regina Maria Papais, Vasconcelos Cláudia Cristina Ferreira
Universidade Federal do Estado do Rio de Janeiro, Departamento de Neurologia, Rio de Janeiro RJ, Brasil.
Instituto Nacional de Câncer, Rio de Janeiro RJ, Brasil.
Arq Neuropsiquiatr. 2017 Mar;75(3):139-141. doi: 10.1590/0004-282X20170010.
Patients with malignant multiple sclerosis (MMS) reach a significant level of disability within a short period of time (Expanded Disability Status Scale score of 6 within five years). The clinical profile and progression of the disease were analyzed in a Brazilian cohort of 293 patients. Twenty-five (8,53%) patients were found to have MMS and were compared with the remaining 268 (91,47%). Women, non-white patients, older age at disease onset, shorter intervals between the first attacks, and more attacks in the first two years of the disease were all more common in the MMS group. These findings could serve as prognostic factors when making therapeutic decisions.
恶性多发性硬化症（MMS）患者在短时间内（五年内扩展残疾状态量表评分为6）会达到严重残疾程度。对巴西一个由293名患者组成的队列中的疾病临床特征和进展进行了分析。发现25名（8.53%）患者患有MMS，并与其余268名（91.47%）患者进行了比较。女性、非白人患者、发病时年龄较大、首次发作之间的间隔较短以及疾病前两年发作次数较多在MMS组中更为常见。这些发现可作为治疗决策时的预后因素。
