90-kDa N结构域血管紧张素I转换酶（ACE）：肾移植模型中高血压的潜在标志物。
90-kDa N-domain angiotensin I-converting enzyme (ACE): possible marker for hypertension in a renal transplant model.
作者信息
Leite Cleber A, Bertoncello Nádia Sc, Watanabe Ingrid Km, Fernandes Fernanda B, Andrade Maria Claudina C, Ronchi Fernanda A, Arita Danielle Y, Marcondes Fernanda K, Cunha Tatiana S, Casarini Dulce E
机构信息
Universidade Federal de São Paulo, Brazil.
Universidade Estadual de Campinas, Brazil.
出版信息
J Bras Nefrol. 2017 Mar;39(1):11-14. doi: 10.5935/0101-2800.20170002.
INTRODUCTION
Hypertension is nearly universal in kidney transplant and several factors are associated with post transplant hypertension, including immunosuppressive medications and genetic predisposition.
OBJECTIVE
The aims were to evaluate the effects of spontaneously hypertensive rats (SHR) kidney transplantation in Wistar rats and the possible transference of 80/90-kDa N-domain ACE.
METHODS
To do so, the data from Wistar recipients of kidney from SHR were compared to data from transplanted Wistar submitted to CsA treatment and, to Wistar Sham.
RESULTS AND DISCUSSION
Despite the unaltered blood pressure observed at early stages, 80/90-kDa ACE was found expressed in the urine of rats 7 and 15 days after transplantation, which was intense when rats became hypertensive 30 days post-surgery.
CONCLUSION
Our data show that this enzyme is associated with the development of hypertension, and this marker appears in the urine before any substantial blood pressure alteration.
引言
高血压在肾移植患者中几乎普遍存在，多种因素与移植后高血压相关，包括免疫抑制药物和遗传易感性。
目的
旨在评估自发性高血压大鼠（SHR）肾脏移植到Wistar大鼠中的效果以及80/90-kDa N-结构域ACE的可能转移情况。
方法
为此，将SHR肾脏移植给Wistar受体的数据与接受环孢素A（CsA）治疗的移植Wistar大鼠以及假手术Wistar大鼠的数据进行比较。
结果与讨论
尽管在早期观察到血压未改变，但在移植后7天和15天大鼠的尿液中发现80/90-kDa ACE表达，在术后30天大鼠出现高血压时表达强烈。
结论
我们的数据表明，这种酶与高血压的发生有关，并且该标志物在任何实质性血压改变之前就出现在尿液中。
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