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1
Treatment of Alopecia Areata With Tofacitinib.他卡西醇治疗斑秃。
JAMA Dermatol. 2017 Jun 1;153(6):600-602. doi: 10.1001/jamadermatol.2017.0001.
2
Successful Treatment of Severe Alopecia Areata With Oral or Topical Tofacitinib.口服或外用托法替布成功治疗重度斑秃
J Drugs Dermatol. 2018 Jul 1;17(7):800-803.
3
Tofacitinib 2% ointment, a topical Janus kinase inhibitor, for the treatment of alopecia areata: A pilot study of 10 patients.2%托法替布软膏，一种局部应用的Janus激酶抑制剂，用于斑秃治疗：一项针对10例患者的初步研究。
J Am Acad Dermatol. 2018 Feb;78(2):403-404.e1. doi: 10.1016/j.jaad.2017.10.043. Epub 2017 Nov 3.
4
Topical tofacitinib in treatment of alopecia areata.局部应用托法替布治疗斑秃。
Einstein (Sao Paulo). 2020;18:eAI5452. doi: 10.31744/einstein_journal/2020ai5452. Epub 2020 Aug 10.
5
Tofacitinib for the treatment of severe alopecia areata and variants: A study of 90 patients.托法替尼治疗严重斑秃及其变异型：90 例患者研究。
J Am Acad Dermatol. 2017 Jan;76(1):22-28. doi: 10.1016/j.jaad.2016.09.007. Epub 2016 Nov 2.
6
Treatment of an alopecia areata patient with tofacitinib results in regrowth of hair and changes in serum and skin biomarkers.用托法替布治疗斑秃患者可导致毛发再生以及血清和皮肤生物标志物的变化。
Exp Dermatol. 2016 Aug;25(8):642-3. doi: 10.1111/exd.13060.
7
Tofacitinib therapy for children with severe alopecia areata.托法替布治疗儿童重度斑秃
J Am Acad Dermatol. 2019 Apr;80(4):1164-1166. doi: 10.1016/j.jaad.2018.12.041. Epub 2019 Jan 8.
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Successful Treatment of Refractory Alopecia Areata Universalis and Psoriatic Arthritis, But Not of Plaque Psoriasis with Tofacitinib in a Young Woman.托法替布成功治疗一名年轻女性的难治性全秃和银屑病关节炎，但对斑块状银屑病无效
Acta Derm Venereol. 2017 Feb 8;97(2):283-284. doi: 10.2340/00015555-2491.
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Therapeutic synergy between contact dermatitis from a wig-fixing device and tofacitinib on alopecia areata.
J Dermatol. 2019 Apr;46(4):e139-e140. doi: 10.1111/1346-8138.14644. Epub 2018 Sep 11.
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Tofacitinib for the treatment of alopecia areata and variants in adolescents.托法替尼治疗青少年斑秃及变异型。
J Am Acad Dermatol. 2017 Jan;76(1):29-32. doi: 10.1016/j.jaad.2016.09.006. Epub 2016 Nov 2.

引用本文的文献

1
Efficacy and Safety of Topical Tofacitinib for the Treatment of Alopecia Areata.局部用托法替布治疗斑秃的疗效与安全性。
Indian Dermatol Online J. 2024 Jun 26;15(4):624-629. doi: 10.4103/idoj.idoj_535_23. eCollection 2024 Jul-Aug.
2
Comparison of efficacy and safety of tofacitinib and azathioprine in patients with alopecia areata and variants: a double-blind, randomized controlled trial.比较托法替尼和硫唑嘌呤治疗斑秃及其变异型的疗效和安全性：一项双盲、随机对照试验。
Arch Dermatol Res. 2024 Jul 5;316(7):458. doi: 10.1007/s00403-024-03203-w.
3
A Real-World Study of Steroid-Free Monotherapy with Tofacitinib in Severe and Therapy-Recalcitrant Alopecia Areata, Alopecia Totalis, and Alopecia Universalis Cases: A Retrospective Analysis.托法替布无类固醇单药治疗重度及治疗抵抗性斑秃、全秃和普秃病例的真实世界研究：一项回顾性分析
Indian Dermatol Online J. 2023 Nov 7;15(1):49-54. doi: 10.4103/idoj.idoj_131_23. eCollection 2024 Jan-Feb.
4
Treatments for Moderate-to-Severe Alopecia Areata: A Systematic Narrative Review.中度至重度斑秃的治疗：系统叙述性综述
Dermatol Ther (Heidelb). 2023 Dec;13(12):2951-2991. doi: 10.1007/s13555-023-01044-5. Epub 2023 Oct 13.
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Refractory Palmoplantar Pustulosis Successfully Treated with JAK Inhibitor Tofacitinib: A Case Series.用JAK抑制剂托法替布成功治疗难治性掌跖脓疱病：病例系列
Infect Drug Resist. 2023 Aug 9;16:5165-5172. doi: 10.2147/IDR.S421299. eCollection 2023.
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The evaluation of JAK inhibitors on effect and safety in alopecia areata: a systematic review and meta-analysis of 2018 patients.JAK 抑制剂治疗斑秃的疗效和安全性评价：2018 例患者的系统评价和荟萃分析。
Front Immunol. 2023 Jun 2;14:1195858. doi: 10.3389/fimmu.2023.1195858. eCollection 2023.
7
The potential of regulatory T cell-based therapies for alopecia areata.基于调节性 T 细胞的疗法治疗斑秃的潜力。
Front Immunol. 2023 May 2;14:1111547. doi: 10.3389/fimmu.2023.1111547. eCollection 2023.
8
Safety of Janus Kinase inhibitors in Patients with Alopecia Areata: A Systematic Review.Janus 激酶抑制剂在斑秃患者中的安全性：系统评价。
Clin Drug Investig. 2023 May;43(5):325-334. doi: 10.1007/s40261-023-01260-z. Epub 2023 May 3.
9
Hidradenitis Suppurativa and JAK Inhibitors: A Review of the Published Literature.化脓性汗腺炎和 JAK 抑制剂：已发表文献综述。
Medicina (Kaunas). 2023 Apr 20;59(4):801. doi: 10.3390/medicina59040801.
10
Tofacitinib reduces acute lung injury and improves survival in a rat model of sepsis by inhibiting the JAK-STAT/NF-κB pathway.托法替布通过抑制JAK-STAT/NF-κB信号通路减轻大鼠脓毒症模型中的急性肺损伤并提高生存率。
J Inflamm (Lond). 2023 Feb 3;20(1):5. doi: 10.1186/s12950-023-00332-3.

本文引用的文献

1
Oral ruxolitinib induces hair regrowth in patients with moderate-to-severe alopecia areata.口服芦可替尼可诱导中重度斑秃患者毛发生长。
JCI Insight. 2016 Sep 22;1(15):e89790. doi: 10.1172/jci.insight.89790.
2
Safety and efficacy of the JAK inhibitor tofacitinib citrate in patients with alopecia areata.托法替尼枸橼酸盐治疗斑秃患者的安全性和疗效。
JCI Insight. 2016 Sep 22;1(15):e89776. doi: 10.1172/jci.insight.89776.
3
Treatment of an alopecia areata patient with tofacitinib results in regrowth of hair and changes in serum and skin biomarkers.用托法替布治疗斑秃患者可导致毛发再生以及血清和皮肤生物标志物的变化。
Exp Dermatol. 2016 Aug;25(8):642-3. doi: 10.1111/exd.13060.
4
Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition.斑秃由细胞毒性 T 淋巴细胞驱动，并可被 JAK 抑制逆转。
Nat Med. 2014 Sep;20(9):1043-9. doi: 10.1038/nm.3645. Epub 2014 Aug 17.
5
Alopecia areata investigational assessment guidelines--Part II. National Alopecia Areata Foundation.斑秃研究评估指南——第二部分。美国斑秃基金会。
J Am Acad Dermatol. 2004 Sep;51(3):440-7. doi: 10.1016/j.jaad.2003.09.032.

他卡西醇治疗斑秃。

Treatment of Alopecia Areata With Tofacitinib.

机构信息

Department of Dermatology, Cleveland Clinic Foundation, Cleveland, Ohio.

出版信息

JAMA Dermatol. 2017 Jun 1;153(6):600-602. doi: 10.1001/jamadermatol.2017.0001.

DOI:10.1001/jamadermatol.2017.0001
PMID:28355451
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5817614/
Abstract

This medical record review describes the characteristics and outcomes of patients with alopecia areata before and after treatment with tofacitinib.

摘要

本病历回顾描述了接受托法替尼治疗前后斑秃患者的特征和结局。