[Effect of the mediation of the taurine on striatum tissue Ca(2+) homeostasis in manganese exposed rats].

To elucidate the effect of taurine on neurotoxicity induced by Mn by investigating activities of Na(+)-K(+)-ATPase and Ca(2+)-Mg(2+)-ATPase and content of Mn and active calmodulin in manganese exposed rats. 156 male SD rats were randomly divided into 1 control group, 3 manganese exposed groups (10, 15, and 20 mg/kg respectively) , and 9 taurine intervened groups based on orthogonal design (doses of taurine intervention were 100, 150, and 200 mg/kg respectively) , with 12 rats in each group. After 12 weeks of exposure, all rats were decapitated and corpus striatums were removed, activities of Na(+)-K(+)-ATPase and Ca(2+)-Mg(2+)-ATPase and content of Mn and active calmodulin were analyzed. The corpus striatum Mn content of the 3 dose groups exposed to Mn and 9 taurine intervened groups were significantly higher than that of the control group (<0.05) . Active calmodulin content in 10 mg/kg manganese exposed group was significantly higher than that of the control group (<0.05) . 150 and 200 mg/kg of taurine could decrease active calmodulin content of the group exposed to 10 mg/kg of Mn (<0.05) . The corpus striatum activities of Na(+)-K(+)-ATPase and Ca(2+)-Mg(2+)-ATPase of the 3 dose groups exposed to Mn were significantly lower than that of the control group (<0.05) . 150 mg/kg of taurine could increase activities of Na(+)-K(+)-ATPase of the group exposed to 10 mg/kg of Mn (<0.05) . 150 and 200 mg/kg of taurine could respectively improve activities of Ca(2+)-Mg(2+)-ATPase of the group exposed to 15, 10 mg/kg of Mn (<0.05) . Mn can decrease the rats corpus striatum activities of Na(+)-K(+)-ATPase and Ca(2+)-Mg(2+)-ATPase, effect level of active calmodulin in relation to dose of Mn, to a certain extent, taurine could regulate activities of Na(+)-K(+)-ATPase and Ca(2+)-Mg(2+)-ATPase and improve the level of active calmodulin.