Raeymaekers H H, Borghys D, Eisendrath H
Vrije Universiteit Brussel, Physics Department, Belgium.
Magn Reson Med. 1988 Feb;6(2):212-6. doi: 10.1002/mrm.1910060209.
Water proton T1 (10.7 MHz; 7 degrees C) and albumin and globulin contents were measured in the blood serum of 30 normal volunteers. The T1 relaxivity of serum albumin and globulin (i.e., the change of water relaxation rate 1/T1 per concentration unit) was determined in pure albumin and globulin solutions. It is shown that more than 90% of the serum relaxation rate 1/T1 is due to the proteins, making T1 a nonspecific blood parameter. In addition five pathological serum samples were examined, explaining clearly why serum T1 is not a clinically useful measurement.
在30名正常志愿者的血清中测量了水质子T1（10.7兆赫；7摄氏度）以及白蛋白和球蛋白含量。在纯白蛋白和球蛋白溶液中测定了血清白蛋白和球蛋白的T1弛豫率（即每浓度单位水弛豫率1/T1的变化）。结果表明，超过90%的血清弛豫率1/T1归因于蛋白质，这使得T1成为一个非特异性的血液参数。此外，还检测了五个病理性血清样本，清楚地解释了为什么血清T1不是一项临床有用的测量指标。
