Turaihi K, D'Souza V, Wakeling A, Dandona P
Department of Chemical Pathology and Human Metabolism, Royal Free Hospital, London, United Kingdom.
Metabolism. 1988 May;37(5):486-90. doi: 10.1016/0026-0495(88)90051-0.
Leukocyte Na-K ATPase was assessed in ten patients with anorexia nervosa. The indices of Na-K ATPase measured were 86Rb influx and [3H]-ouabain binding. Both 86Rb influx and [3H]-ouabain binding were significantly lower in patients with anorexia nervosa than in controls. Following weight gain (4.1 to 11.9 kg) in seven patients both 86Rb influx and [3H]-ouabain binding increased in each patient to levels similar to those in controls, although the patients still remained underweight. Acute oral glucose challenge (75 g) also resulted in an increase in 86Rb influx and [3H]-ouabain binding in each of the eight patients tested. There was a significant correlation between 86Rb influx and [3H]-ouabain binding. We conclude that the leukocytes of patients with anorexia nervosa have a significantly diminished number of Na-K ATPase units with a parallel decrease in 86Rb influx. Weight gain and acute glucose challenge result in an increase in both indices of Na-K ATPase. Nutrition appears to play an important role in the modulation of this enzyme.
对10名神经性厌食症患者的白细胞钠钾ATP酶进行了评估。所测量的钠钾ATP酶指标为86Rb流入量和[3H]-哇巴因结合量。神经性厌食症患者的86Rb流入量和[3H]-哇巴因结合量均显著低于对照组。7名患者体重增加（4.1至11.9千克）后，每名患者的86Rb流入量和[3H]-哇巴因结合量均增加至与对照组相似的水平，尽管这些患者仍体重不足。对8名受试患者进行急性口服葡萄糖激发试验（75克）后，每名患者的86Rb流入量和[3H]-哇巴因结合量也均增加。86Rb流入量与[3H]-哇巴因结合量之间存在显著相关性。我们得出结论，神经性厌食症患者的白细胞钠钾ATP酶单位数量显著减少，同时86Rb流入量也相应降低。体重增加和急性葡萄糖激发试验均导致钠钾ATP酶的这两个指标增加。营养似乎在该酶的调节中起重要作用。
