O'Donnell D
Department of General Medicine, Fremantle Hospital, WA.
Med J Aust. 1988 May 16;148(10):525-7. doi: 10.5694/j.1326-5377.1988.tb99465.x.
Deterioration in renal function after the use of angiotensin converting-enzyme inhibitors may be the first clue to the presence of bilateral renal arterial stenosis. In order to avoid serious threat to the patient, early detection of the insidious decline in renal function is necessary and depends on routine biochemical monitoring after the initiation of therapy. Six cases are described here, to illustrate the very real danger of this class of drugs in this chemical setting; the grave risk of their combination with potassium-sparing diuretic agents is highlighted.
使用血管紧张素转换酶抑制剂后肾功能恶化可能是双侧肾动脉狭窄存在的首个线索。为避免对患者造成严重威胁，必须尽早发现隐匿性肾功能减退，这依赖于治疗开始后的常规生化监测。本文描述了6例病例，以说明这类药物在这种化学环境中的真实危险；强调了它们与保钾利尿剂联合使用的严重风险。
