Morotomi Nobuo, Saitoh Masakazu, Ishii Noriko, Ohno Kayoko, Nagayama Masatoshi, Kawate Nobuyuki, Mizuma Masazumi
Department of Home Care, Yumino Heart Clinic, Japan; Department of Rehabilitation Medicine, Showa University, Japan.
Department of Physiotherapy, Sakakibara Heart Institute, Japan.
J Phys Ther Sci. 2017 Mar;29(3):425-431. doi: 10.1589/jpts.29.425. Epub 2017 Mar 22.
[Purpose] Although cardiac rehabilitation (CR) is recommended for patients with chronic heart failure (CHF), adequate exercise effect cannot be obtained in elderly patients. Administration of amino acids (AA) to CHF patients has been reported to improve exercise capacity, but the changes in AA composition in plasma before and after CR had not been reported. This study aimed to measure plasma levels of AA in CHF patients and compare with values of normal range. In addition the relationship between the change of exercise capacity and AA were examined. [Subjects and Methods] Twelve CHF patients (60% males, aged 68 ± 12 years) were studied. The correction between the rates of changes in exercise capacity parameters and in plasma AA levels was investigated. [Results] Anaerobic threshold (AT) and peak oxygen uptake (VO) improved significantly after CR. The AA profile showed no specific pattern, and citrulline (Cit) was the amino acid showing a significant positive correlation with exercise capacity (∆Cit vs. ∆AT: r=0.602, ∆Cit vs. ∆AT-work rate (WR): r=0.681, ∆Cit vs. ∆VO/WR: r=0.635). A tendency of positive correlation was observed between ∆Cit and ∆peak VO (r=0.456). [Conclusion] The AA profile showed no specific pattern, but a relationship between change in exercise capacity and Cit were found.
[目的] 尽管推荐慢性心力衰竭（CHF）患者进行心脏康复（CR），但老年患者无法获得足够的运动效果。据报道，对CHF患者给予氨基酸（AA）可提高运动能力，但CR前后血浆中AA组成的变化尚未见报道。本研究旨在测定CHF患者血浆中AA水平，并与正常范围值进行比较。此外，还研究了运动能力变化与AA之间的关系。[对象与方法] 对12例CHF患者（男性占60%，年龄68±12岁）进行了研究。研究了运动能力参数变化率与血浆AA水平变化率之间的相关性。[结果] CR后无氧阈值（AT）和峰值摄氧量（VO）显著改善。AA谱无特定模式，瓜氨酸（Cit）是与运动能力呈显著正相关的氨基酸（∆Cit与∆AT：r=0.602，∆Cit与∆AT-工作率（WR）：r=0.681，∆Cit与∆VO/WR：r=0.635）。∆Cit与∆峰值VO之间观察到正相关趋势（r=0.456）。[结论] AA谱无特定模式，但发现运动能力变化与Cit之间存在关系。
