Sánchez-Recillas Amanda, Arroyo-Herrera Ana Ly, Araujo-León Jesús Alfredo, Hernández Núñez Emanuel, Ortiz Andrade Rolffy
Laboratorio de Farmacología, Facultad de Química, Universidad Autónoma de Yucatán, Mérida, YUC, Mexico.
Laboratorio de Cromatografía, Facultad de Química, Universidad Autónoma de Yucatán, Mérida, YUC, Mexico.
Evid Based Complement Alternat Med. 2017;2017:3960837. doi: 10.1155/2017/3960837. Epub 2017 Mar 5.
Antibacterial activity on ATCC strains of , , and and spasmolytic effect on contraction on rat ileum trips were determinate. Eight organic extracts (hexanic and methanolic) of albedo (mesocarp) and flavedo (pericarp) of two varieties (Valencian and National) of (L.) Osbeck of Yucatán, México, were studied. Additionally, chromatographic fingerprints were obtained and correlated with their pharmacological effects. MAN, MAV, and HFN extract caused inhibition against (MIC: 1000 g/mL) and (MIC: 1000 g/mL). Regarding the spasmolytic effect, the Valencian extracts variety was more efficient on spontaneous contraction, HAV ( = 51.98 ± 1.98%), MAV ( = 35.98 ± 1.42%), HFV ( = 68.91 ± 4.14%), and MFV ( = 51.28 ± 2.59%), versus National variety, HAN ( = 43.80 ± 6.32%), MAN ( = 14.62 ± 1.69%), HFN ( = 64.87 ± 3.04%), and MFN ( = 31.01 ± 3.92%). Chromatographic fingerprints of HFV and HFN were found to have some similar signals that belong to monoterpenes, whereas for HAN and HAV similar signals were found belonging to fatty acids and triterpenoids. Methanolic extracts showed signals of (1) furfural, (2) furfural acetone (3) furfuraldehyde and (4) -sitosterol compounds. Flavedo portion of possessed spasmolytic effect on rat ileum strips and antibacterial activity against strains. This species is source for obtaining bioactive compounds with therapeutic potential in the treatment of infectious diarrhea.
测定了对ATCC的、、和菌株的抗菌活性以及对大鼠回肠收缩的解痉作用。研究了墨西哥尤卡坦州（L.）奥斯贝克两个品种（巴伦西亚和国家品种）的果皮（中果皮）和外果皮（果皮）的八种有机提取物（己烷和甲醇提取物）。此外，还获得了色谱指纹图谱并将其与药理作用相关联。MAN、MAV和HFN提取物对（MIC：1000 g/mL）和（MIC：1000 g/mL）有抑制作用。关于解痉作用，巴伦西亚提取物品种对自发收缩更有效，HAV（= 51.98 ± 1.98%）、MAV（= 35.98 ± 1.42%）、HFV（= 68.91 ± 4.14%）和MFV（= 51.28 ± 2.59%），而国家品种的HAN（= 43.80 ± 6.32%）、MAN（= 14.62 ± 1.69%）、HFN（= 64.87 ± 3.04%）和MFN（= 31.01 ± 3.92%）。发现HFV和HFN的色谱指纹图谱有一些属于单萜的相似信号，而对于HAN和HAV，发现相似信号属于脂肪酸和三萜类化合物。甲醇提取物显示出（1）糠醛、（2）糠醛丙酮（3）糠醛和（4）β-谷甾醇化合物的信号。的外果皮部分对大鼠回肠条有解痉作用，对菌株有抗菌活性。该物种是获得具有治疗感染性腹泻治疗潜力的生物活性化合物的来源。
