Chapman G E, Greenwood C E
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Ontario.
Neurochem Res. 1988 Jan;13(1):77-82. doi: 10.1007/BF00971858.
The effect of taurine on rat and hamster brain Na,K-ATPase was examined and compared to norepinephrine (NE) stimulation of the enzyme. Although NE stimulation of microsomal Na,K-ATPase was observed in the presence of the cell cytosolic fraction, taurine was without effect in the presence and absence of this fraction. Taurine also failed to modulate pubescent and mature hamster brain Na,K-ATPase. Presence or absence of ion chelators did not change taurine's effect. These results are discussed in relation to previous reports of taurine and catecholamine stimulation of Na,K-ATPase.
研究了牛磺酸对大鼠和仓鼠脑钠钾-ATP酶的作用，并与去甲肾上腺素（NE）对该酶的刺激作用进行了比较。尽管在存在细胞胞质部分的情况下观察到NE对微粒体钠钾-ATP酶有刺激作用，但无论有无该部分，牛磺酸均无作用。牛磺酸也未能调节青春期和成年仓鼠脑钠钾-ATP酶。离子螯合剂的存在与否并未改变牛磺酸的作用。结合先前关于牛磺酸和儿茶酚胺刺激钠钾-ATP酶的报道对这些结果进行了讨论。
