Chen Xiaoyi, Zhao Huilin, Chen Zhensen, Qiao Huiyu, Cui Yuanyuan, Li Dongye, Zhou Zechen, He Le, Li Rui, Yuan Chun, Zhao Xihai
Center for Brain Disorders Research, Capital Medical University and Beijing Institute for Brain Disorders, Beijing, China.
Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University School of Medicine, Haidian District, Beijing, 100084, China.
Neuroradiology. 2017 May;59(5):485-490. doi: 10.1007/s00234-017-1825-z. Epub 2017 Mar 29.
Significant stenosis or occlusion in carotid arteries may lead to diffuse wall thickening (DWT) in the arterial wall of downstream. This study aimed to investigate the correlation between proximal internal carotid artery (ICA) steno-occlusive disease and DWT in ipsilateral petrous ICA.
Symptomatic patients with atherosclerotic stenosis (>0%) in proximal ICA were recruited and underwent carotid MR vessel wall imaging. The 3D motion sensitized-driven equilibrium prepared rapid gradient-echo (3D-MERGE) was acquired for characterizing the wall thickness and longitudinal extent of the lesions in petrous ICA and the distance from proximal lesion to the petrous ICA. The stenosis degree in proximal ICA was measured on the time-of-flight (TOF) images.
In total, 166 carotid arteries from 125 patients (mean age 61.0 ± 10.5 years, 99 males) were eligible for final analysis and 64 showed DWT in petrous ICAs. The prevalence of severe DWT in petrous ICA was 1.4%, 5.3%, 5.9%, and 80.4% in ipsilateral proximal ICAs with stenosis category of 1%-49%, 50%-69%, 70%-99%, and total occlusion, respectively. Proximal ICA stenosis was significantly correlated with the wall thickness in petrous ICA (r = 0.767, P < 0.001). Logistic regression analysis showed that proximal ICA stenosis was independently associated with DWT in ipsilateral petrous ICA (odds ratio (OR) = 2.459, 95% confidence interval (CI) 1.896-3.189, P < 0.001].
Proximal ICA steno-occlusive disease is independently associated with DWT in ipsilateral petrous ICA.
颈动脉严重狭窄或闭塞可能导致下游动脉壁弥漫性增厚（DWT）。本研究旨在探讨颈内动脉（ICA）近端狭窄闭塞性疾病与同侧岩骨段ICA的DWT之间的相关性。
招募有症状的近端ICA动脉粥样硬化狭窄（>0%）患者，并进行颈动脉磁共振血管壁成像。采用三维运动敏感驱动平衡准备快速梯度回波序列（3D-MERGE）来确定岩骨段ICA病变的壁厚和纵向范围，以及近端病变到岩骨段ICA的距离。在时间飞跃（TOF）图像上测量近端ICA的狭窄程度。
共有来自125例患者（平均年龄61.0±10.5岁，男性99例）的166条颈动脉符合最终分析标准，其中64条在岩骨段ICA显示有DWT。在同侧近端ICA狭窄程度分别为1%-49%、50%-69%、70%-99%和完全闭塞的情况下，岩骨段ICA严重DWT的患病率分别为1.4%、5.3%、5.9%和80.4%。近端ICA狭窄与岩骨段ICA的壁厚显著相关（r=0.767，P<0.001）。逻辑回归分析显示，近端ICA狭窄与同侧岩骨段ICA的DWT独立相关（比值比（OR）=2.459，95%置信区间（CI）1.896-3.189，P<0.001）。
近端ICA狭窄闭塞性疾病与同侧岩骨段ICA的DWT独立相关。
