长期给予丙咪嗪和电休克对脊髓中阿片μ、δ和κ受体无影响。
The lack of effect of chronic administration of imipramine and electroconvulsive shock on opioid mu, delta and kappa receptors in the spinal cord.
作者信息
Antkiewicz-Michaluk L, Vetulani J
机构信息
Department of Biochemistry, Institute of Pharmacology, Polish Academy of Sciences, Kraków.
出版信息
Pol J Pharmacol Pharm. 1987 Jul-Aug;39(4):387-91.
PMID:2835755
Abstract
Chronic administration of imipramine (10 mg/kg/day for 21 days) and ECS (8 daily treatments) did not change parameters of specific spinal binding sites for [3H]naloxone, [3H]DADLE and [3H]bremazocine. The results indicate that chronic antidepressant treatment does not affect spinal opioid receptors.
摘要
慢性给予丙咪嗪（10毫克/千克/天，持续21天）和电惊厥休克（每日8次治疗）并未改变[3H]纳洛酮、[3H]DADLE和[3H]布瑞马唑嗪在脊髓特异性结合位点的参数。结果表明，慢性抗抑郁治疗不会影响脊髓阿片受体。
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