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功能性消化不良临床前模型中的内感受受损。

Impaired Interoception in a Preclinical Model of Functional Dyspepsia.

作者信息

Winston John H, Aguirre Jose E, Shi Xuan-Zheng, Sarna Sushil K

机构信息

Enteric Neuromuscular Disorders and Visceral Pain Center, Division of Gastroenterology and Hepatology, Department of Internal Medicine, The University of Texas Medical Branch at Galveston, McCullough Building, 301 University Blvd. 0764, Galveston, TX, 77555-1083, USA.

Department of Neuroscience and Cell Biology, The University of Texas Medical Branch at Galveston, Galveston, TX, 77555-1083, USA.

出版信息

Dig Dis Sci. 2017 Sep;62(9):2327-2337. doi: 10.1007/s10620-017-4487-0. Epub 2017 Mar 29.

DOI:10.1007/s10620-017-4487-0
PMID:28357695
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5559576/
Abstract

INTRODUCTION: The etiologies of functional dyspepsia symptoms, including postprandial distress syndrome, remain unknown. We tested the hypothesis that neonatal colon inflammation induces postprandial distress syndrome-like symptoms in adult life that associate with increased activation of vagal afferent pathways and forebrain limbic regions. RESULTS: These rats showed a significant decrease in nutrient meal consumption to satiety after an overnight fast, decrease in gastric emptying, decrease in total distance traveled, and decrease in percent distance traveled in midfield versus control rats in open field test, indicating postprandial anxiety- and depression-like behaviors. Adult naïve rats treated with oral iodoacetamide to induce H. pylori-like mild gastritis demonstrated similar postprandial effects as the above rats. CONCLUSIONS: We concluded that neonatal colon inflammation is a risk factor for the development of postprandial distress syndrome-like symptoms. While mild gastritis can induce symptoms similar to those of neonatal colon inflammation, gastritis in these rats does not worsen the symptoms.

摘要

引言：包括餐后不适综合征在内的功能性消化不良症状的病因尚不清楚。我们检验了这样一个假设，即新生儿结肠炎症会在成年后诱发类似餐后不适综合征的症状，这些症状与迷走神经传入通路和前脑边缘区域的激活增加有关。 结果：与对照大鼠相比，这些大鼠在禁食过夜后进食至饱腹感时的营养膳食摄入量显著减少，胃排空减少，总行进距离减少，在旷场试验中中场行进距离百分比减少，表明出现了类似餐后焦虑和抑郁的行为。用口服碘乙酰胺诱导幽门螺杆菌样轻度胃炎的成年未处理大鼠表现出与上述大鼠类似的餐后效应。 结论：我们得出结论，新生儿结肠炎症是发生类似餐后不适综合征症状的一个危险因素。虽然轻度胃炎可诱发与新生儿结肠炎症类似的症状，但这些大鼠的胃炎并未使症状加重。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720a/5559576/a26df741ba8f/10620_2017_4487_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720a/5559576/8d4a1fadf56c/10620_2017_4487_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720a/5559576/574423e87706/10620_2017_4487_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720a/5559576/ee2a67a7c9a7/10620_2017_4487_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720a/5559576/b8712580183b/10620_2017_4487_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720a/5559576/b4d4ecba5003/10620_2017_4487_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720a/5559576/15fb50f61776/10620_2017_4487_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720a/5559576/a26df741ba8f/10620_2017_4487_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720a/5559576/8d4a1fadf56c/10620_2017_4487_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720a/5559576/574423e87706/10620_2017_4487_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720a/5559576/ee2a67a7c9a7/10620_2017_4487_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720a/5559576/b8712580183b/10620_2017_4487_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720a/5559576/b4d4ecba5003/10620_2017_4487_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720a/5559576/15fb50f61776/10620_2017_4487_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720a/5559576/a26df741ba8f/10620_2017_4487_Fig7_HTML.jpg

相似文献

[1]
Impaired Interoception in a Preclinical Model of Functional Dyspepsia.

Dig Dis Sci. 2017-9

[2]
Fasting and postprandial gastric sensorimotor activity in functional dyspepsia: postprandial distress vs. epigastric pain syndrome.

Am J Gastroenterol. 2014-10

[3]
In functional dyspepsia, hypersensitivity to postprandial distention correlates with meal-related symptom severity.

Gastroenterology. 2013-5-20

[4]
A rat model of chronic gastric sensorimotor dysfunction resulting from transient neonatal gastric irritation.

Gastroenterology. 2008-6

[5]
Enhanced sympathetic nerve activity induced by neonatal colon inflammation induces gastric hypersensitivity and anxiety-like behavior in adult rats.

Am J Physiol Gastrointest Liver Physiol. 2016-7-1

[6]
Rapid gastric emptying, rather than delayed gastric emptying, might provoke functional dyspepsia.

J Gastroenterol Hepatol. 2011-4

[7]
The proximal stomach and postprandial symptoms in functional dyspeptics.

Am J Gastroenterol. 2002-1

[8]
Gastrointestinal sensory abnormalities in functional dyspepsia.

Baillieres Clin Gastroenterol. 1998-9

[9]
Postprandial symptoms originating from the stomach in functional dyspepsia.

Neurogastroenterol Motil. 2013-9-2

[10]
Unsuppressed postprandial phasic contractility in the proximal stomach in functional dyspepsia: relevance to symptoms.

Am J Gastroenterol. 2003-10

引用本文的文献

[1]
Electroacupuncture Regulates TRPV1 through PAR2/PKC Pathway to Alleviate Visceral Hypersensitivity in FD Rats.

Evid Based Complement Alternat Med. 2021-11-29

[2]
Choosing an Animal Model for the Study of Functional Dyspepsia.

Can J Gastroenterol Hepatol. 2018-2-12

[3]
Gut Inflammation: More Than a Peripheral Annoyance.

Dig Dis Sci. 2017-9

本文引用的文献

[1]
Catechol-O-methyltransferase inhibition alters pain and anxiety-related volitional behaviors through activation of β-adrenergic receptors in the rat.

Neuroscience. 2015-4-2

[2]
Fasting and postprandial gastric sensorimotor activity in functional dyspepsia: postprandial distress vs. epigastric pain syndrome.

Am J Gastroenterol. 2014-10

[3]
Differential activation of chemically identified neurons in the caudal nucleus of the solitary tract in non-entrained rats after intake of satiating vs. non-satiating meals.

Physiol Behav. 2014-9

[4]
Postprandial symptoms originating from the stomach in functional dyspepsia.

Neurogastroenterol Motil. 2013-9-2

[5]
In functional dyspepsia, hypersensitivity to postprandial distention correlates with meal-related symptom severity.

Gastroenterology. 2013-5-20

[6]
Impaired duodenal mucosal integrity and low-grade inflammation in functional dyspepsia.

Gut. 2013-3-8

[7]
Functional dyspepsia--symptoms, definitions and validity of the Rome III criteria.

Nat Rev Gastroenterol Hepatol. 2013-2-12

[8]
Developmental origins of functional dyspepsia-like gastric hypersensitivity in rats.

Gastroenterology. 2012-11-8

[9]
Why dyspepsia can occur without organic disease: pathogenesis and management of functional dyspepsia.

J Gastroenterol. 2012-7-6

[10]
Transient gastric irritation in the neonatal rats leads to changes in hypothalamic CRF expression, depression- and anxiety-like behavior as adults.

PLoS One. 2011-5-12

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