Scollon Sarah, Anglin Amanda Knoth, Thomas Martha, Turner Joyce T, Wolfe Schneider Kami
Department of Pediatrics, Baylor College of Medicine, Texas Children's Cancer Center, Texas Children's Hospital, 1102 Bates St, FC 1200, Houston, TX, 77030, USA.
Myriad Genetic Laboratories, Dayton, OH, USA.
J Genet Couns. 2017 Jun;26(3):387-434. doi: 10.1007/s10897-017-0077-8. Epub 2017 Mar 29.
An understanding of the role of inherited cancer predisposition syndromes in pediatric tumor diagnoses continues to develop as more information is learned through the application of genomic technology. Identifying patients and their relatives at an increased risk for developing cancer is an important step in the care of this patient population. The purpose of this review is to highlight various tumor types that arise in the pediatric population and the cancer predisposition syndromes associated with those tumors. The review serves as a guide for recognizing genes and conditions to consider when a pediatric cancer referral presents to the genetics clinic.
随着通过基因组技术的应用获得了更多信息，人们对遗传性癌症易感性综合征在儿科肿瘤诊断中的作用的认识也在不断发展。识别患癌风险增加的患者及其亲属是照顾这一患者群体的重要一步。本综述的目的是强调儿科人群中出现的各种肿瘤类型以及与这些肿瘤相关的癌症易感性综合征。该综述可作为一份指南，用于识别在儿科癌症转诊至遗传学诊所时需要考虑的基因和病症。
