Lueg M C
Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112.
South Med J. 1988 May;81(5):597-600.
Eleven menopausal patients were treated for 12 to 18 months with low-dose sodium fluoride and calcium. Six patients also received estrogen replacement. A significant increase in spine or hip bone mineral density measured by dual photon absorptiometry was observed in all patients. The estrogen-treated group had the greatest increase in bone density. Addition of estrogen seems to supplement bone gain and allow sodium fluoride to be administered in lower doses, which are easily tolerated and yet effective.
11名绝经患者接受了低剂量氟化钠和钙治疗12至18个月。6名患者还接受了雌激素替代治疗。通过双能光子吸收法测量，所有患者的脊柱或髋部骨矿物质密度均显著增加。接受雌激素治疗的组骨密度增加最大。添加雌激素似乎有助于增加骨量，并允许以较低剂量使用氟化钠，这些较低剂量易于耐受且有效。
