The IFN-1 > BID > ROS pathway: Linking DNA damage with HSPC malfunction.
作者信息
Gross Atan, Tasdogan Alpaslan, Fehling Hans Joerg
机构信息
a Department of Biological Regulation , Weizman Institute of Science , Rehovot , Israel.
b Institute of Immunology , University Hospital , Ulm , Germany.
出版信息
Cell Cycle. 2017 May 3;16(9):819-820. doi: 10.1080/15384101.2017.1304742. Epub 2017 Mar 30.
Abstract
摘要
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Cell Stem Cell. 2016 Dec 1;19(6):752-767. doi: 10.1016/j.stem.2016.08.007. Epub 2016 Sep 15.
2
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DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity.DNA 损伤通过细胞质 DNA 传感器 STING 激活 I 型干扰素系统，以促进抗微生物先天免疫。
Immunity. 2015 Feb 17;42(2):332-343. doi: 10.1016/j.immuni.2015.01.012.
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The ATM-BID pathway regulates quiescence and survival of haematopoietic stem cells.ATM-BID 通路调节造血干细胞的静止和存活。
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IFNalpha activates dormant haematopoietic stem cells in vivo.干扰素α在体内激活休眠的造血干细胞。
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