Lu Yunhe, Bao Nan, Ghanem Abdulsamad, Cai Tianyi, Yang Junyi, Mu Xiongzheng
*Division of Plastic and Reconstructive Surgery, Huashan Hospital, Fudan University†Department of Neurosurgery, Shanghai Children's Medica Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
J Craniofac Surg. 2017 Sep;28(6):1425-1430. doi: 10.1097/SCS.0000000000003589.
This is the first Eastern center-based retrospective report on early complications and associated perioperative factors of nonsyndromic craniosynostosis (NSC). The authors' purpose is to tailor preoperative counseling, convey objective perioperative data, and determinants for early complications in NSC so as to enhance exchanges with international center. Inclusion criteria required a diagnosis of NSC confirmed by 3-dimentional computed tomography scans and complete medical record. Genetic evidence of syndromic craniosynostosis was excluded. Study population was divided into 4 groups based on the suture involvement, which were compared with respect to demographics, perioperative factors, and the occurrence of complications. Demographic data were analyzed using descriptive statistics. Categorical variables were analyzed using the Fisher exact test. Continuous variables were analyzed using the Kruskal-Wallis test. To better study key determinants for early complications, regression analysis was performed. It revealed a predominance of sagittal (n = 36) throughout the time period studied. Eastern China (n = 33) and Southwest China (n = 13) were the top 2 districts where patients came. The authors also reported an overall rate of early complication of 80% (n = 52). The most common were pyrexia (n = 50). Blood loss was a risk (P = 0.041; OR, 1.102); meanwhile, transfusion of concentrated red blood cells was a higher risk (P = 0.035; OR, 2.033). This study represents the authors' initial 4 years practice in NSC. The authors are endeavoring to enhance exchanges with Western centers.
这是首份基于东方中心的关于非综合征性颅缝早闭（NSC）早期并发症及相关围手术期因素的回顾性报告。作者的目的是调整术前咨询，传达客观的围手术期数据以及NSC早期并发症的决定因素，以加强与国际中心的交流。纳入标准要求通过三维计算机断层扫描和完整病历确诊为NSC。排除综合征性颅缝早闭的遗传证据。研究人群根据受累缝线分为4组，并就人口统计学、围手术期因素和并发症的发生情况进行比较。人口统计学数据采用描述性统计分析。分类变量采用Fisher精确检验分析。连续变量采用Kruskal-Wallis检验分析。为更好地研究早期并发症的关键决定因素，进行了回归分析。结果显示在整个研究期间矢状缝受累占主导（n = 36）。中国东部（n = 33）和中国西南部（n = 13）是患者来源最多的两个地区。作者还报告早期并发症的总体发生率为80%（n = 52）。最常见的是发热（n = 50）。失血是一个风险因素（P = 0.041；OR，1.102）；同时，输注浓缩红细胞风险更高（P = 0.035；OR，2.033）。本研究代表了作者在NSC方面最初4年的实践。作者正努力加强与西方中心的交流。
