Bailey Timothy S, Stone Jenine Y
a AMCR Institute , Escondido , CA , USA.
Expert Opin Drug Deliv. 2017 May;14(5):697-703. doi: 10.1080/17425247.2017.1313831. Epub 2017 Apr 10.
Diabetes is growing in prevalence internationally. As more individuals require insulin as part of their treatment, technology evolves to optimize delivery, improve adherence, and reduce dosing errors. Insulin pens outperform vial and syringe in simplicity, dosing accuracy, and user preference. Bolus advisors improve dosing confidence and treatment adherence. The InPen System offers a novel approach to treatment via a wireless pen that syncs to a mobile application featuring a bolus advisor, enabling convenient insulin dose tracking and more accurate bolus advice among other features. Areas covered: Existing technology for insulin delivery and bolus advice are reviewed. The mechanics and functionality of the InPen device are delineated. Findings from formative testing and usability studies of the InPen system are reported. Future directions for the InPen system in the treatment of diabetes are discussed. Expert opinion: Diabetes management is complex and largely data-driven. The InPen System offers a promising new opportunity to avail insulin pen-users of features known to improve treatment efficacy, which have otherwise primarily been available to those using pumps. Given that the majority of insulin users do not use insulin pumps, the InPen System is poised to improve glucose control in a significant portion of the diabetes population.
糖尿病在全球的患病率正在上升。随着越来越多的人需要使用胰岛素进行治疗，技术不断发展以优化给药方式、提高依从性并减少给药错误。胰岛素笔在简易性、给药准确性和用户偏好方面优于小瓶和注射器。大剂量给药辅助器可提高给药信心和治疗依从性。InPen系统通过一款无线笔提供了一种新颖的治疗方法，该笔可与一款具有大剂量给药辅助器功能的移动应用程序同步，具备方便的胰岛素剂量跟踪以及更准确的大剂量给药建议等功能。涵盖领域：对现有的胰岛素给药和大剂量给药建议技术进行了综述。阐述了InPen设备的原理和功能。报告了InPen系统的形成性测试和可用性研究结果。讨论了InPen系统在糖尿病治疗方面的未来发展方向。专家观点：糖尿病管理很复杂，且很大程度上由数据驱动。InPen系统为胰岛素笔用户提供了一个充满希望的新机会，使其能够使用那些已知可提高治疗效果的功能，而这些功能以前主要是使用胰岛素泵的用户才能享有的。鉴于大多数胰岛素使用者不使用胰岛素泵，InPen系统有望改善很大一部分糖尿病患者的血糖控制。
