医科大学与非医科大学健康学生之间耐甲氧西林金黄色葡萄球菌的鼻腔携带情况。

Methicillin-resistant Staphylococcus aureus nasal carriage between healthy students of medical and nonmedical universities.

作者信息

Abroo Soleiman, Hosseini Jazani Nima, Sharifi Yaeghob

机构信息

Department of Microbiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, West Azarbyjan, Iran.

Department of Microbiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, West Azarbyjan, Iran; Cellular and Molecular Research Center, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, West Azarbyjan, Iran.

出版信息

Am J Infect Control. 2017 Jul 1;45(7):709-712. doi: 10.1016/j.ajic.2017.02.034. Epub 2017 Mar 27.

DOI:10.1016/j.ajic.2017.02.034

PMID:28359610

Abstract

BACKGROUND

Methicillin-resistant Staphylococcus aureus (MRSA) is a challenge for public health, and community-acquired (CA) infections seem to be increasing among people in different areas.

METHODS

A total of 700 healthy student volunteers residing in dormitories of universities in Urmia, Iran, were enrolled in this study. After identification of the isolates, antibiotic susceptibility, presence of mecA and pvl genes, and staphylococcal cassette chromosome mec (SCCmec) typing were evaluated.

RESULTS

Nasal screening identified 137 (19.6%) carriers of S aureus, and 18 (13.14%) were MRSA isolates. The antimicrobial susceptibility patterns of isolates revealed high resistance to penicillin (93.4%). All isolates were sensitive to vancomycin. The SCCmec typing showed that most MRSA strains belonged to SCCmec type IV (n = 14; 77.8%). Only 1 (5.56%) MRSA isolates carried the pvl gene.

CONCLUSIONS

Our findings revealed the relatively high frequency of S aureus nasal carriers and the advent of multidrug resistance among these isolates. Most MRSA isolates were SCCmec type IV; the transfer of such MRSA strains from carriers to other individuals in crowded living conditions such as dormitories can act as a risk factor for outbreak of CA MRSA and is a serious threat for the study groups.

摘要

背景

耐甲氧西林金黄色葡萄球菌（MRSA）对公共卫生构成挑战，并且社区获得性（CA）感染在不同地区的人群中似乎呈上升趋势。

方法

本研究纳入了伊朗乌尔米耶市大学宿舍中的700名健康学生志愿者。分离株鉴定后，评估抗生素敏感性、mecA和pvl基因的存在情况以及葡萄球菌盒式染色体mec（SCCmec）分型。

结果

鼻腔筛查发现137名（19.6%）金黄色葡萄球菌携带者，其中18株（13.14%）为MRSA分离株。分离株的抗菌药敏模式显示对青霉素高度耐药（93.4%）。所有分离株对万古霉素敏感。SCCmec分型显示，大多数MRSA菌株属于SCCmec IV型（n = 14；77.8%）。只有1株（5.56%）MRSA分离株携带pvl基因。