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Preventing acquisition of HIV is the only path to an AIDS-free generation.

作者信息

Corey Lawrence, Gray Glenda E

机构信息

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109;

Department of Laboratory Medicine, University of Washington, Seattle, WA 98195.

出版信息

Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3798-3800. doi: 10.1073/pnas.1703236114. Epub 2017 Mar 30.

DOI:10.1073/pnas.1703236114
PMID:28360202
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5393193/
Abstract
摘要

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Preventing acquisition of HIV is the only path to an AIDS-free generation.预防感染艾滋病毒是实现无艾滋病一代的唯一途径。
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Protecting the health of our AIDS-free generation: beyond prevention of mother-to-child HIV transmission.保护我们这一代无艾滋病者的健康:超越预防母婴传播艾滋病毒
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HIV transmission (sexuality, blood, semen, placenta).艾滋病毒传播(性行为、血液、精液、胎盘)。
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HIV and AIDS. 2. Modes of transmission, testing for HIV antibodies, and occupational exposure to HIV.艾滋病毒与艾滋病。2. 传播方式、艾滋病毒抗体检测及职业性接触艾滋病毒
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Preventing mother-to-child transmission of human immunodeficiency virus infection.预防人类免疫缺陷病毒感染的母婴传播。
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Current controversies in the treatment of HIV infection and AIDS. An economic perspective.HIV感染与艾滋病治疗中的当前争议:经济学视角
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Preventing perinatal HIV: prenatal HIV testing and strategies to reduce the risk of maternal--fetal HIV transmission.预防围产期艾滋病毒感染:产前艾滋病毒检测及降低母婴艾滋病毒传播风险的策略
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AIDS deaths decline.艾滋病死亡人数下降。
AIDS Clin Care. 1997 Apr;9(4):36, 33.

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Targeting and vaccine durability are key for population-level impact and cost-effectiveness of a pox-protein HIV vaccine regimen in South Africa.针对南非痘病毒蛋白 HIV 疫苗方案的人群影响和成本效益,靶向性和疫苗耐久性是关键。
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本文引用的文献

1
Can the UNAIDS 90-90-90 target be achieved? A systematic analysis of national HIV treatment cascades.联合国艾滋病规划署的90-90-90目标能够实现吗?对各国艾滋病治疗流程的系统分析。
BMJ Glob Health. 2016 Sep 15;1(2):e000010. doi: 10.1136/bmjgh-2015-000010. eCollection 2016.
2
Effectiveness of UNAIDS targets and HIV vaccination across 127 countries.UNAIDS 目标和 HIV 疫苗在 127 个国家的效果。
Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):4017-4022. doi: 10.1073/pnas.1620788114. Epub 2017 Mar 20.
3
Sweden, the first country to achieve the Joint United Nations Programme on HIV/AIDS (UNAIDS)/World Health Organization (WHO) 90-90-90 continuum of HIV care targets.瑞典是首个实现联合国艾滋病规划署(UNAIDS)/世界卫生组织(WHO)提出的艾滋病治疗90-90-90连续目标的国家。
HIV Med. 2017 Apr;18(4):305-307. doi: 10.1111/hiv.12431. Epub 2016 Aug 18.
4
Projected economic evaluation of the national implementation of a hypothetical HIV vaccination program among adolescents in South Africa, 2012.2012年南非青少年中假设的艾滋病毒疫苗接种计划全国实施的预计经济评估。
BMC Public Health. 2016 Apr 14;16:330. doi: 10.1186/s12889-016-2959-3.
5
Are Clade Specific HIV Vaccines a Necessity? An Analysis Based on Mathematical Models.基于数学模型的分析:分支特异性 HIV 疫苗是否有必要?
EBioMedicine. 2015 Nov 5;2(12):2062-9. doi: 10.1016/j.ebiom.2015.11.009. eCollection 2015 Dec.
6
Safety, pharmacokinetics and neutralization of the broadly neutralizing HIV-1 human monoclonal antibody VRC01 in healthy adults.健康成年人中广泛中和HIV-1的人单克隆抗体VRC01的安全性、药代动力学及中和作用
Clin Exp Immunol. 2015 Dec;182(3):289-301. doi: 10.1111/cei.12692. Epub 2015 Sep 24.
7
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.在非洲开展的早期抗逆转录病毒治疗和异烟肼预防治疗试验。
N Engl J Med. 2015 Aug 27;373(9):808-22. doi: 10.1056/NEJMoa1507198. Epub 2015 Jul 20.
8
Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection.早期无症状HIV感染中抗逆转录病毒治疗的启动
N Engl J Med. 2015 Aug 27;373(9):795-807. doi: 10.1056/NEJMoa1506816. Epub 2015 Jul 20.
9
Potential future impact of a partially effective HIV vaccine in a southern African setting.一种部分有效的HIV疫苗在南部非洲环境中的潜在未来影响。
PLoS One. 2014 Sep 10;9(9):e107214. doi: 10.1371/journal.pone.0107214. eCollection 2014.
10
Prevention of HIV-1 infection with early antiretroviral therapy.早期抗逆转录病毒疗法预防 HIV-1 感染。
N Engl J Med. 2011 Aug 11;365(6):493-505. doi: 10.1056/NEJMoa1105243. Epub 2011 Jul 18.