Güven Sertaç, Kesebir Sermin, Demirer R Murat, Bilici Mustafa
Clinic of Psychiatry, Sandıklı State Hospital, Kütahya, Turkey.
Department of Psychiatry, Humanities and Social Sciences Faculty, İstanbul, Turkey.
Noro Psikiyatr Ars. 2015 Jun;52(2):194-197. doi: 10.5152/npa.2015.7180. Epub 2015 Jun 1.
Our aim in this study was to investigate spectral power density (PSD) in first-episode mania and subsequent remission period and to evaluate their difference.
Sixty-nine consecutive cases referring to our hospital within the previous 1 year, who were evaluated as bipolar disorder manic episode according to The Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV) at the first episode and had the informed consent form signed by first degree relatives, were included in this study. Exclusion criteria included having previous depressive episode, using drugs which could influence electroencephalographic activity before electroencephalography (EEG), and having previous neurological disease, particularly epilepsy, head trauma, and/or loss of consciousness. EEG records were obtained using a digital device in 16 channels; 23 surface electrodes were placed according to the International 10-20 system. Spectral power density (dbμV/Hz) of EEG signal provided information on the power carried out by EEG waves in defined frequancy range per unit frequency in the present study.
A peak power value detected on the right with FP2P4 and on the left with F7T3 electrodes were found to be higher in the manic episode than in the remission period (p=0.018 and 0.025). In the remission period, in cases with psychotic symptoms during the manic period, F4C4 peak power value was found to be lower than that in cases with no psychotic findings during the manic period (p=0.027). There was no relation was found between YMRS scores and peak power scores.
Electrophysiological corollary of mood episode is present from the onset of the disease, and it differs between the manic and remission periods of bipolar disorder. In the remission period, peak power values of PSD distinguish cases with psychotic findings from cases without psychotic findings when they were manic.
本研究的目的是调查首发躁狂发作及随后缓解期的频谱功率密度（PSD），并评估它们之间的差异。
在过去1年中连续转诊至我院的69例患者被纳入本研究，这些患者在首发时根据《精神疾病诊断与统计手册》第四版（DSM-IV）被评估为双相情感障碍躁狂发作，且其一级亲属签署了知情同意书。排除标准包括既往有抑郁发作史、在脑电图（EEG）检查前使用过可能影响脑电图活动的药物、既往有神经系统疾病，尤其是癫痫、头部外伤和/或意识丧失。使用数字设备获取16通道的EEG记录；根据国际10-20系统放置23个表面电极。在本研究中，EEG信号的频谱功率密度（dbμV/Hz）提供了EEG波在定义频率范围内每单位频率所携带功率的信息。
发现FP2P4电极右侧和F7T3电极左侧检测到的峰值功率值在躁狂发作期高于缓解期（p = 0.018和0.025）。在缓解期，躁狂期有精神病性症状的患者，F4C4峰值功率值低于躁狂期无精神病性表现的患者（p = 0.027）。未发现杨氏躁狂量表（YMRS）评分与峰值功率评分之间存在关联。
情绪发作的电生理推论从疾病发作时就存在，并且在双相情感障碍的躁狂期和缓解期有所不同。在缓解期，PSD的峰值功率值可区分躁狂发作时有精神病性表现的患者和无精神病性表现的患者。
