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Hyperleukocytosis during clozapine treatment: A rare presentation of B-cell Acute lymphoblastic leukemia.氯氮平治疗期间的白细胞增多症：B细胞急性淋巴细胞白血病的罕见表现。
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Can we prevent blood dyscrasia (leucopenia, thrombocytopenia) and epileptic seizures induced by clozapine.能否预防氯氮平引起的血液学异常（白细胞减少症、血小板减少症）和癫痫发作。
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[Clozapine-associated neuroleptic malignant syndrome followed by catatonia: a case report].[氯氮平相关的抗精神病药恶性综合征继发紧张症：一例报告]
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Neutropenia and agranulocytosis during treatment of schizophrenia with clozapine versus other antipsychotics: an observational study in Iceland.氯氮平与其他抗精神病药物治疗精神分裂症期间的中性粒细胞减少症和粒细胞缺乏症：冰岛的一项观察性研究
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COVID-19 in People With Schizophrenia: Potential Mechanisms Linking Schizophrenia to Poor Prognosis.精神分裂症患者的新冠病毒病：将精神分裂症与预后不良联系起来的潜在机制
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本文引用的文献

1
Chronic leukocytosis associated with clozapine treatment.与氯氮平治疗相关的慢性白细胞增多症。
Clin Schizophr Relat Psychoses. 2010 Jul;4(2):141-4. doi: 10.3371/CSRP.4.2.6.
2
Chronic leukocytosis associated with clozapine: a case series.氯氮平相关的慢性白细胞增多症：病例系列
J Clin Psychiatry. 2007 Mar;68(3):484-8. doi: 10.4088/jcp.v68n0320b.
3
Clozapine induces oxidative stress and proapoptotic gene expression in neutrophils of schizophrenic patients.氯氮平可诱导精神分裂症患者中性粒细胞产生氧化应激和促凋亡基因表达。
J Clin Psychopharmacol. 2005 Oct;25(5):419-26. doi: 10.1097/01.jcp.0000177668.42640.fe.
4
Increased clozapine plasma concentrations and side effects induced by smoking cessation in 2 CYP1A2 genotyped patients.2例CYP1A2基因分型患者戒烟后氯氮平血药浓度升高及出现副作用。
Ther Drug Monit. 2005 Aug;27(4):539-43. doi: 10.1097/01.ftd.0000164609.14808.93.
5
Role of the smoking-induced cytochrome P450 (CYP)1A2 and polymorphic CYP2D6 in steady-state concentration of olanzapine.吸烟诱导的细胞色素P450（CYP）1A2和多态性CYP2D6在奥氮平稳态浓度中的作用。
J Clin Psychopharmacol. 2003 Apr;23(2):119-27. doi: 10.1097/00004714-200304000-00003.
6
Clozapine-induced blood dyscrasias.氯氮平所致血液系统异常。
Haematologica. 2000;85(E-letters):E02.
7
Reducing clozapine-related morbidity and mortality: 5 years of experience with the Clozaril National Registry.降低氯氮平相关的发病率和死亡率：氯氮平国家登记处5年的经验
J Clin Psychiatry. 1998;59 Suppl 3:3-7.
8
Clozapine--deciphering the risks.
N Engl J Med. 1993 Jul 15;329(3):204-5. doi: 10.1056/NEJM199307153290312.
9
Chronic leukocytosis and neutrophilia caused by rehabilitation stress in a clozapine-treated patient.氯氮平治疗患者因康复应激导致的慢性白细胞增多和嗜中性粒细胞增多。
Pharmacopsychiatry. 1993 May;26(3):99. doi: 10.1055/s-2007-1014350.
10
Clozapine and leukocytosis.氯氮平和白细胞增多症。
J Clin Psychopharmacol. 1995 Aug;15(4):286-7. doi: 10.1097/00004714-199508000-00010.

氯氮平治疗慢性精神分裂症患者后出现白细胞增多症。

Leukocytosis after Clozapine Treatment in a Patient with Chronic Schizophrenia.

作者信息

Polat Aslıhan, Çakir Uğur, Gündüz Nermin

机构信息

Department of Psychiatry, Kocaeli University School of Medicine, Kocaeli, Turkey.

Department of Psychiatry, Abant İzzet Baysal University School of Medicine, Bolu, Turkey.

出版信息

Noro Psikiyatr Ars. 2016 Mar;53(1):87-88. doi: 10.5152/npa.2015.9855. Epub 2016 Mar 1.

DOI:10.5152/npa.2015.9855
PMID:28360774
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5353246/
Abstract

Clozapine is an atypical antipsychotic drug that is approved by the US Food and Drug Administration (FDA) for the treatment of psychotic disorders. Agranulocytosis is a well-established side effect of clozapine; clozapine has also been associated with other blood dyscrasias like leukocytosis, albeit rarely. In this paper, we aim to report a case of possible clozapine-associated leukocytosis in a 41-year-old woman.

摘要

氯氮平是一种非典型抗精神病药物，已被美国食品药品监督管理局（FDA）批准用于治疗精神障碍。粒细胞缺乏症是氯氮平已被确认的副作用；氯氮平也与其他血液系统疾病如白细胞增多有关，尽管这种情况很少见。在本文中，我们旨在报告一例41岁女性可能与氯氮平相关的白细胞增多病例。