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2
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J Affect Disord. 2016 Jun;197:189-95. doi: 10.1016/j.jad.2016.03.043. Epub 2016 Mar 11.
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Expert Rev Neurother. 2010 Nov;10(11):1637-58. doi: 10.1586/ern.10.143.
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[Rationale for the use of long-acting injectable risperidone: a survey of French psychiatrists].[使用长效注射用利培酮的基本原理:法国精神科医生的一项调查]
Encephale. 2013 May;39 Suppl 1:S8-14. doi: 10.1016/j.encep.2012.03.005. Epub 2013 Mar 28.
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Mania, glutamate/glutamine and risperidone in pediatric bipolar disorder: a proton magnetic resonance spectroscopy study of the anterior cingulate cortex.小儿双相情感障碍中的躁狂、谷氨酸/谷氨酰胺与利培酮:前扣带回皮质的质子磁共振波谱研究
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A Retrospective Study of Long Acting Risperidone Use to Support Treatment Adherence in Youth with Conduct Disorder.一项关于使用长效利培酮以支持品行障碍青少年治疗依从性的回顾性研究。
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本文引用的文献

1
Long-acting injectable formulations of new-generation antipsychotics: a review from a clinical perspective.长效新一代抗精神病药物注射制剂:从临床角度的综述。
CNS Drugs. 2013 Aug;27(8):637-52. doi: 10.1007/s40263-013-0083-9.
2
Long-acting risperidone: a review of its role in the treatment of bipolar disorder.长效利培酮:其在双相情感障碍治疗中作用的综述
Adv Ther. 2009 Jun;26(6):588-99. doi: 10.1007/s12325-009-0039-0. Epub 2009 Jun 26.
3
Systematic overview of Cochrane reviews for anticholinergic effects of antipsychotic drugs.抗精神病药物抗胆碱能作用的Cochrane综述系统概述。
J Clin Psychopharmacol. 2009 Apr;29(2):141-6. doi: 10.1097/JCP.0b013e31819a91f1.
4
Use of risperidone long-acting injection to support treatment adherence and mood stabilization in pediatric bipolar patients: a case series.使用利培酮长效注射剂支持儿童双相情感障碍患者的治疗依从性和情绪稳定:病例系列
J Clin Psychiatry. 2009 Apr;70(4):604-6. doi: 10.4088/jcp.08l04487.
5
Review of risperidone for the treatment of pediatric and adolescent bipolar disorder and schizophrenia.利培酮治疗儿童和青少年双相情感障碍及精神分裂症的评价。
Neuropsychiatr Dis Treat. 2008 Feb;4(1):55-68.
6
Weight gain and metabolic effects of mood stabilizers and antipsychotics in pediatric bipolar disorder: a systematic review and pooled analysis of short-term trials.心境稳定剂和抗精神病药物对儿童双相情感障碍的体重增加及代谢影响:短期试验的系统评价与汇总分析
J Am Acad Child Adolesc Psychiatry. 2007 Jun;46(6):687-700. doi: 10.1097/chi.0b013e318040b25f.
7
Treatment adherence with antipsychotic medications in bipolar disorder.双相情感障碍中抗精神病药物的治疗依从性。
Bipolar Disord. 2006 Jun;8(3):232-41. doi: 10.1111/j.1399-5618.2006.00314.x.
8
An open-label trial of risperidone in children and adolescents with bipolar disorder.一项关于利培酮治疗双相情感障碍儿童和青少年的开放标签试验。
J Child Adolesc Psychopharmacol. 2005 Apr;15(2):311-7. doi: 10.1089/cap.2005.15.311.
9
Long-term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD).双相情感障碍早发的长期影响:来自双相情感障碍系统治疗强化项目(STEP-BD)首批1000名参与者的数据。
Biol Psychiatry. 2004 May 1;55(9):875-81. doi: 10.1016/j.biopsych.2004.01.022.
10
Atypical antipsychotics in the treatment of children and adolescents: clinical applications.非典型抗精神病药物在儿童和青少年治疗中的临床应用
J Clin Psychiatry. 2004;65 Suppl 6:30-44.

长效注射用利培酮在一名11岁双相情感障碍儿童中的应用

Long-acting Injectable Risperidone Use in an 11-Years-Old Bipolar Child.

作者信息

Karakoç Demirkaya Sevcan, Zoroğlu Süleyman Salih

机构信息

Department of Child and Adolescent Psychiatry, Adnan Menderes University School of Medicine, Aydın, Turkey.

Department of Child and Adolescent Psychiatry, İstanbul University İstanbul School of Medicine, İstanbul, Turkey.

出版信息

Noro Psikiyatr Ars. 2016 Dec;53(4):361-363. doi: 10.5152/npa.2015.10150. Epub 2016 Apr 15.

DOI:10.5152/npa.2015.10150
PMID:28360814
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5353046/
Abstract

Early-onset bipolar disorder is difficult for child psychiatrists in terms of both diagnosis and treatment. The proper diagnostic evaluation is negatively impacted by the atypical clinical manifestation and rapid cycling pattern of the disease, together with common comorbidity with attention-deficit hyperactivity disorder and anxiety disorder. In addition to poor insight, nonadherence to treatment, poor family coping skills, and insufficient child psychiatric inpatient units make clinicians unsuccessful in following up and treating such patients. Risperidone is a commonly used atypical antipsychotic it has been approved for the treatment of manic and mixed episodes of bipolar disorder even in 10-17-year-old patients, and it is commonly used. It has a long-acting injectable formulation. Studies on its long-acting form in younger children are limited. In this case presentation, the diagnostic procedure in an 11-year old child with bipolar disorder will be presented. Long-acting injectable risperidone use in the case of nonadherence to treatment and observed side effects will be discussed.

摘要

早发性双相情感障碍对于儿童精神科医生来说,在诊断和治疗方面都颇具难度。该疾病非典型的临床表现、快速循环模式,以及与注意力缺陷多动障碍和焦虑症的常见共病情况,对正确的诊断评估产生了负面影响。除了洞察力差、不依从治疗、家庭应对能力差之外,儿童精神科住院单元不足也使得临床医生在随访和治疗这类患者时难以取得成效。利培酮是一种常用的非典型抗精神病药物,它已被批准用于治疗双相情感障碍的躁狂和混合发作,甚至适用于10至17岁的患者,且应用广泛。它有一种长效注射剂型。针对年幼儿童使用其长效剂型的研究有限。在本病例报告中,将呈现一名11岁双相情感障碍患儿的诊断过程。还将讨论在不依从治疗的情况下使用长效注射用利培酮以及观察到的副作用。