Department of Pharmacy Practice, University of Illinois at Chicago College of Pharmacy Chicago, IL, USA.
Neuropsychiatr Dis Treat. 2008 Feb;4(1):55-68.
Risperidone is a commonly used medication for the treatment of bipolar disorder and schizophrenia in children and adolescents. It has been studied as a monotherapy treatment in early onset schizophrenia and as both monotherapy and combination therapy for pediatric bipolar disorder. Studies to date indicate that risperidone is an effective treatment for positive and negative symptoms of schizophrenia and mania symptoms of bipolar disorder. In young patient populations, side effects such as weight gain, extrapyramidal side effects, and prolactin elevation require consideration when evaluating the risk benefit ratio for individual patients. Here we review published studies of risperidone for the treatment of bipolar disorder and schizophrenia in children and adolescents to provide practitioners with an overview of published data on the efficacy and safety of risperidone in these patient populations.
利培酮是一种常用于治疗儿童和青少年双相情感障碍和精神分裂症的药物。它已被研究作为早期精神分裂症的单药治疗，以及儿科双相情感障碍的单药和联合治疗。迄今为止的研究表明，利培酮是治疗精神分裂症阳性和阴性症状以及双相情感障碍躁狂症状的有效药物。在年轻患者人群中，在评估个体患者的风险效益比时，需要考虑体重增加、锥体外系副作用和催乳素升高等副作用。在这里，我们回顾了已发表的关于利培酮治疗儿童和青少年双相情感障碍和精神分裂症的研究，为从业者提供了关于利培酮在这些患者群体中的疗效和安全性的已发表数据概述。
