Cho A-Ra, Choi Won-Jun, Kim Shin-Hye, Shim Jae-Yong, Lee Yong-Jae
Department of Family Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Korean J Fam Med. 2017 Mar;38(2):75-80. doi: 10.4082/kjfm.2017.38.2.75. Epub 2017 Mar 22.
White blood cell count is an independent risk factor for cardiovascular disease. Several lifestyle and metabolic factors such as cigarette smoking and obesity are known to be associated with an elevated white blood cell count. However, the joint effect of cigarette smoking and obesity on white blood cell count has not yet been fully described.
We explored the joint effect of cigarette smoking and obesity on white blood cell count using multiple logistic regression analyses after adjusting for confounding variables in a population-based, cross-sectional study of 416,065 Korean adults.
Cigarette smoking and body mass index have a dose-response relationship with a higher white blood cell count, but no synergistic interaction is observed between them (men, P for interaction=0.797; women, P for interaction=0.311). Cigarette smoking and body mass index might have an additive combination effect on high white blood cell count. Obese male smokers were 2.36 times more likely and obese female smokers 2.35 times more likely to have a high white blood cell count when compared with normal body mass index non-smokers.
Cigarette smoking and body mass index are independently associated with an elevated white blood cell count in both men and women.
白细胞计数是心血管疾病的独立危险因素。已知吸烟和肥胖等几种生活方式及代谢因素与白细胞计数升高有关。然而，吸烟和肥胖对白细胞计数的联合作用尚未得到充分描述。
在一项针对416,065名韩国成年人的基于人群的横断面研究中，我们在对混杂变量进行调整后，使用多元逻辑回归分析探讨了吸烟和肥胖对白细胞计数的联合作用。
吸烟和体重指数与较高的白细胞计数存在剂量反应关系，但两者之间未观察到协同相互作用（男性，交互作用P值 = 0.797；女性，交互作用P值 = 0.311）。吸烟和体重指数可能对高白细胞计数具有相加组合效应。与正常体重指数的非吸烟者相比，肥胖男性吸烟者白细胞计数高的可能性是其2.36倍，肥胖女性吸烟者白细胞计数高的可能性是其2.35倍。
吸烟和体重指数在男性和女性中均与白细胞计数升高独立相关。
