Fernandez-Obregon A C, Forconi R J
Department of Dermatology, Naval Hospital, Portsmouth, Virginia.
Cutis. 1988 May;41(5):347-50.
The clinical picture of neuropathy caused by dapsone is usually progressive muscle weakness and wasting, most often involving distal muscles of the extremities. Two patients with neurologic symptoms following the use of dapsone for dermatitis herpetiformis are reported. Both patients had normal motor conduction velocities, and negative results on physical examination of muscle wasting. We conclude that their clinical presentation was not due to dapsone-induced neuropathy. A discussion and a review of cases of this unusual effect of dapsone are included.
氨苯砜引起的神经病变的临床表现通常为进行性肌肉无力和萎缩，最常累及四肢远端肌肉。本文报告了2例因使用氨苯砜治疗疱疹样皮炎而出现神经症状的患者。两名患者的运动传导速度均正常，肌肉萎缩体格检查结果为阴性。我们得出结论，他们的临床表现并非由氨苯砜引起的神经病变所致。本文还对氨苯砜这种不寻常作用的病例进行了讨论和综述。
