南非农村地区孕妇抗逆转录病毒药物的自我报告及干血斑测量作为依从性标志物的研究
Self-Report and Dry Blood Spot Measurement of Antiretroviral Medications as Markers of Adherence in Pregnant Women in Rural South Africa.
作者信息
Alcaide Maria L, Ramlagan Shandir, Rodriguez Violeta J, Cook Ryan, Peltzer Karl, Weiss Stephen M, Sifunda Sibusiso, Jones Deborah L
机构信息
Division of Infectious Diseases, Department of Medicine, University of Miami Miller School of Medicine, 1120 NW 14 Street, CRB 864 (D-90A), Miami, FL, 33136, USA.
HIV/AIDS/STIs and TB (HAST) Research Programme, Human Sciences Research Council, Pretoria, South Africa.
出版信息
AIDS Behav. 2017 Jul;21(7):2135-2140. doi: 10.1007/s10461-017-1760-3.
Abstract
Antiretroviral (ARV) adherence is essential to prevent mother-to-child transmission of HIV. This study compared self-reported adherence versus ARV detection in dried blood spots (DBS) among N = 392 HIV-infected pregnant women in South Africa (SA). Women completed two self-reported adherence measures [visual analog scale (VAS), AIDS Clinical Trials Group Adherence (ACTG)]. Adherence was 89% (VAS), 80% (ACTG), and 74% (DBS). Self-report measures marginally agreed with DBS (VAS: Kappa = 0.101, Area under the ROC curve (AUROC) = 0.543; ACTG: Kappa = 0.081, AUROC = 0.538). Self-reported adherence was overestimated and agreement with DBS was poor. Validation of self-reported ARV adherence among pregnant HIV+ women in SA is needed.
摘要
抗逆转录病毒（ARV）药物依从性对于预防艾滋病毒母婴传播至关重要。本研究比较了南非（SA）392名感染艾滋病毒的孕妇自我报告的依从性与干血斑（DBS）中ARV检测结果。女性完成了两项自我报告的依从性测量[视觉模拟量表（VAS）、艾滋病临床试验组依从性（ACTG）]。依从性分别为89%（VAS）、80%（ACTG）和74%（DBS）。自我报告测量结果与DBS结果仅有微弱的一致性（VAS：kappa = 0.101，ROC曲线下面积（AUROC）= 0.543；ACTG：kappa = 0.081，AUROC = 0.538）。自我报告的依从性被高估，与DBS的一致性较差。南非感染艾滋病毒的孕妇中自我报告的ARV依从性需要进行验证。
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