Müller A, Zollmann C, Machnik G, Krombholz B, Reinhardt M, Jorke D
Department of Internal Medicine, Friedrich Schiller University of Jena.
Dtsch Z Verdau Stoffwechselkr. 1988;48(1):27-34.
The activities of enzymes collagen peptidase (CP), monoaminoxidase (MAO) and N-acetyl-beta-D-glucosaminidase (beta-NAG) in the serum are related to the development of hepatic fibrosis. These enzymes were determined in the sera of 121 liver-biopsied patients who were subdivided by morphological criteria into 4 different grades of fibrosis (0 to greater than or equal to 3). CP shows the best correlation with the extent of fibrosis. beta-NAG, indeed, bears of relationship to the morphologically proven extent of fibrosis, however, significant increases in activity are also encountered in patients with liver diseases, but without liver fibrosis. The validity of these fibrosis markers is calculated in order to differentiate between low- and high-grade fibrosis. With a sensitivity of 86% and a specificity of 92%, CP possesses the best predictive value of 85.7%. The results can still be improved by the combination of CP and beta-NAG.
血清中胶原肽酶（CP）、单胺氧化酶（MAO）和N-乙酰-β-D-氨基葡萄糖苷酶（β-NAG）的活性与肝纤维化的发展相关。对121例接受肝脏活检的患者血清中的这些酶进行了检测，这些患者根据形态学标准被分为4个不同等级的纤维化（0至大于或等于3级）。CP与纤维化程度的相关性最佳。实际上，β-NAG与形态学证实的纤维化程度有关，然而，在患有肝脏疾病但无肝纤维化的患者中也会出现活性显著增加的情况。计算这些纤维化标志物的有效性以区分低级别和高级别纤维化。CP的敏感性为86%，特异性为92%，具有85.7%的最佳预测价值。通过将CP和β-NAG联合使用，结果仍可得到改善。
