Manku M S, Morse-Fisher N, Horrobin D F
Efamol Research Institute, Kentville, Nova Scotia, Canada.
Eur J Clin Nutr. 1988 Jan;42(1):55-60.
Administration of doses of linoleic acid (LA) up to 36 g/d in humans raised blood levels of linoleic acid but not of its metabolites. This is probably because the conversion of LA to gamma-linolenic acid (GLA) is slow and rate-limiting. We have found that administration of relatively small amounts of GLA, up to 360 mg/d, raises human blood levels of dihomogammalinolenic acid (DGLA) and arachidonic acid (AA).
在人体中每日给予高达36克的亚油酸（LA）剂量会提高血液中亚油酸水平，但不会提高其代谢产物的水平。这可能是因为亚油酸向γ-亚麻酸（GLA）的转化缓慢且为限速过程。我们发现，给予相对少量的γ-亚麻酸，每日高达360毫克，会提高人体血液中二高γ-亚麻酸（DGLA）和花生四烯酸（AA）的水平。
