代谢途径进一步增加了出芽酵母细胞大小控制的复杂性。
Metabolic pathways further increase the complexity of cell size control in budding yeast.
作者信息
Enserink Jorrit M
机构信息
Oslo University Hospital, Department of Microbiology, Sognsvannsveien 20, NO-0027 Oslo, Norway.
出版信息
Microb Cell. 2014 Aug 22;1(9):276-278. doi: 10.15698/mic2014.09.167.
Abstract
How organisms regulate their size is a major question in biology. With a few notable exceptions (such as cell divisions in the early embryo), most cells need to reach a critical size in order to initiate a new cell cycle. How cells set a critical cell size, and how they know it has been reached, is not well understood. Using various types of experimental systems, decades ago two main models were proposed for cell size homeostasis: the deterministic model and the probabilistic model.
摘要
生物体如何调节其大小是生物学中的一个主要问题。除了少数显著的例外情况（如早期胚胎中的细胞分裂），大多数细胞需要达到一个临界大小才能启动新的细胞周期。细胞如何设定临界细胞大小，以及它们如何知道已达到该大小，目前还不太清楚。几十年前，利用各种类型的实验系统，人们提出了两种主要的细胞大小稳态模型：确定性模型和概率性模型。
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