Skovlund Charlotte Wessel, Kessing Lars Vedel, Mørch Lina Steinrud, Lidegaard Øjvind
a Department of Gynaecology, Rigshospitalet, Faculty of Health Science , University of Copenhagen , Denmark.
b Psychiatric Centre, Rigshospitalet, Faculty of Health Science , University of Copenhagen , Denmark.
Nord J Psychiatry. 2017 Jul;71(5):378-385. doi: 10.1080/08039488.2017.1305445. Epub 2017 Mar 31.
To analyse trends in depression diagnoses and antidepressant use according to age and gender.
Nationwide cohort study including all women and men of 10-49 years living in Denmark during 2000-2013. The Psychiatric Registry and Prescription Registry provided data on depression diagnoses and antidepressant medication, respectively. Incidence rates as well as 1-year prevalence rates were calculated.
The incidence and 1-year prevalence rates of depression diagnoses increased during 2000-2013. The women/men rates were 2.0 for both 1-year prevalence of depressions diagnoses and antidepressant use. For adolescent girls, the absolute increase was 3 per 1000 for depression diagnoses and 8 per 1000 for first use of antidepressants, compared to boys who had an increase of 1.1 and 3 per 1000, respectively. Before puberty, boys and girls had almost the same incidence rates of both depression diagnoses and antidepressant use throughout the period. After puberty, girls had significantly higher incidence rates than boys, and experienced during the study period a steeper increase than boys. According to age, the girls/boys incidence rate ratio of a depression diagnosis increased from 0.8 in the 10-11 year age group to 2.7 at age 12-19 years and hereafter decreased with increasing age to 1.5 at age 45-49.
Depression diagnosed and first use of antidepressants increased more for girls of 12-19 years than for boys during 2000-2013, and the incidences were similar for girls and boys before puberty, but higher after puberty for girls.
根据年龄和性别分析抑郁症诊断及抗抑郁药使用情况的趋势。
全国性队列研究，纳入2000年至2013年期间居住在丹麦的所有10至49岁的女性和男性。精神病学登记处和处方登记处分别提供了抑郁症诊断和抗抑郁药物的数据。计算发病率以及1年患病率。
2000年至2013年期间，抑郁症诊断的发病率和1年患病率有所上升。抑郁症诊断的1年患病率和抗抑郁药使用的女性/男性比率均为2.0。对于青春期少女，抑郁症诊断的绝对增加量为每1000人中有3例，首次使用抗抑郁药的增加量为每1000人中有8例，而男孩的增加量分别为每1000人中有1.1例和3例。在青春期前，男孩和女孩在整个时期的抑郁症诊断和抗抑郁药使用发病率几乎相同。青春期后，女孩的发病率明显高于男孩，并且在研究期间比男孩经历了更陡峭的上升。按年龄划分，抑郁症诊断的女孩/男孩发病率比率从10至11岁年龄组的0.8增加到12至19岁年龄组的2.7，此后随着年龄的增加而下降，在45至49岁时降至1.5。
2000年至2013年期间，12至19岁女孩的抑郁症诊断和抗抑郁药首次使用的增加幅度大于男孩，青春期前女孩和男孩的发病率相似，但青春期后女孩的发病率更高。
