Miller J H, Wilson W E, Swenberg C E, Myers L S, Charlton D E
Pacific Northwest Laboratory, Richland, Washington 99352.
Int J Radiat Biol Relat Stud Phys Chem Med. 1988 Jun;53(6):901-7. doi: 10.1080/09553008814551261.
Monte Carlo simulation techniques were used to calculate the probability that thymine radical anions (T.-), formed by the slowing-down of high-energy protons in oriented DNA, will undergo a secondary protonation reaction. By assuming a large asymmetry in the thermal conductivity of oriented DNA fibres we predict a significant enhancement of protonation of T.- when the proton flux is incident on the sample parallel to the orientation of the DNA. These results are in qualitative agreement with experimental data on the production of TH. radicals when oriented DNA is exposed to fast neutrons.
采用蒙特卡罗模拟技术来计算由高能质子在定向DNA中慢化形成的胸腺嘧啶自由基阴离子（T.-）发生二次质子化反应的概率。通过假设定向DNA纤维的热导率存在很大的不对称性，我们预测当质子流平行于DNA的取向入射到样品上时，T.-的质子化会显著增强。这些结果与定向DNA暴露于快中子时TH.自由基产生的实验数据在定性上是一致的。
