上肢损伤后异位骨化
Heterotopic Ossification Following Upper Extremity Injury.
作者信息
Agarwal Shailesh, Loder Shawn, Levi Benjamin
机构信息
Section of Plastic Surgery, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA.
Section of Plastic Surgery, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA.
出版信息
Hand Clin. 2017 May;33(2):363-373. doi: 10.1016/j.hcl.2016.12.013.
Abstract
Heterotopic ossification (HO) presents a substantial barrier to rehabilitation for patients with severe burns or trauma. Although surgical excision is a mainstay of management for this condition, this is unable to address the chronic sequelae of HO, including chronic pain, joint contractures, nerve dysfunction, and open wounds. Current therapeutic modalities are aimed at excision and the prevention of recurrence using nonsteroidal antiinflammatory drugs (NSAIDs) or radiation therapy. Research is now focused on identifying alternative strategies to prevent the initial occurrence of HO through NSAIDs and novel inhibitors of the bone morphogenetic protein signaling pathway.
摘要
异位骨化（HO）对严重烧伤或创伤患者的康复构成了重大障碍。尽管手术切除是这种病症治疗的主要手段，但这无法解决HO的慢性后遗症，包括慢性疼痛、关节挛缩、神经功能障碍和开放性伤口。目前的治疗方式旨在通过使用非甾体抗炎药（NSAIDs）或放射疗法进行切除并预防复发。现在的研究重点是确定通过NSAIDs和骨形态发生蛋白信号通路的新型抑制剂来预防HO初次发生的替代策略。
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