胃旁路手术对中国肥胖 2 型糖尿病患者颈动脉内膜中层厚度的影响。

Effect of Roux-en-Y gastric bypass on carotid intima-media thickness in Chinese obese patients with type 2 diabetes.

机构信息

Department of Ultrasound in Medicine, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Institute of Ultrasound in Medicine, Shanghai, China.

Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Jiao Tong University Afﬁliated Sixth People's Hospital, Shanghai, China.

出版信息

Surg Obes Relat Dis. 2017 Sep;13(9):1530-1535. doi: 10.1016/j.soard.2017.01.039. Epub 2017 Feb 3.

DOI:10.1016/j.soard.2017.01.039

PMID:28363402

Abstract

BACKGROUND

The effect of Roux-en-Y gastric bypass (RYGB) on carotid intima-media thickness (C-IMT) in obese patients with type 2 diabetes (T2D) has not been well studied.

OBJECTIVE

To investigate the effect of RYGB on C-IMT and the relationship between C-IMT and some cardiovascular risk factors 12 months after surgery on Chinese obese patients with T2D.

SETTING

University hospital, China.

METHODS

Thirty-three consecutive obese patients with T2D and 18 healthy volunteers matched in age and sex were enrolled in this retrospective study. The anthropometric data, metabolism variables, and C-IMT were recorded before and 12 months after RYGB.

RESULTS

The patient group had significantly higher C-IMT than the control group before surgery (589.5±96.9 μm versus 457.9±48.6 μm, respectively; P<.01). C-IMT had significant positive relationships with age, body mass index, systolic blood pressure, visceral fat area (VFA), and serum leptin (r = .56, .44, .38, .42, and .38, respectively; P<.01). Twelve months after RYGB, the anthropometric data, metabolism variables, and C-IMT had improved signiﬁcantly. The change in C-IMT was positively correlated with changes in VFA and leptin level (r = .39 and .36, respectively; P<.01).

CONCLUSION

RYGB surgery seems to be effective on C-IMT for obese patients with T2D in China. VFA and leptin level are related to improvement of C-IMT.

摘要

背景

Roux-en-Y 胃旁路术（RYGB）对 2 型糖尿病（T2D）肥胖患者颈动脉内膜中层厚度（C-IMT）的影响尚未得到很好的研究。

目的

探讨 RYGB 对 C-IMT 的影响以及 C-IMT 与术后 12 个月中国肥胖 T2D 患者一些心血管危险因素的关系。

设置

中国大学医院。

方法

这项回顾性研究纳入了 33 例连续肥胖 T2D 患者和 18 例年龄和性别相匹配的健康志愿者。记录了 RYGB 前后的人体测量数据、代谢变量和 C-IMT。

结果

术前患者组的 C-IMT 明显高于对照组（589.5±96.9μm比 457.9±48.6μm，P<.01）。C-IMT 与年龄、体重指数、收缩压、内脏脂肪面积（VFA）和血清瘦素呈显著正相关（r =.56，.44，.38，.42 和.38，P<.01）。RYGB 术后 12 个月，人体测量数据、代谢变量和 C-IMT 均显著改善。C-IMT 的变化与 VFA 和瘦素水平的变化呈正相关（r =.39 和.36，P<.01）。