VA VISN 2 Center for Excellence for Suicide Prevention, Canandaigua VA Medical Center, Canandaigua, NY, USA; Department of Psychiatry, University of Rochester Medical Center, Rochester, NY, USA.
VA VISN 2 Center for Excellence for Suicide Prevention, Canandaigua VA Medical Center, Canandaigua, NY, USA; Department of Psychiatry, University of Rochester Medical Center, Rochester, NY, USA.
J Psychiatr Res. 2017 Sep;92:1-7. doi: 10.1016/j.jpsychires.2017.03.011. Epub 2017 Mar 19.
The goal of this study was to examine the relationship between past-year frequency of prescription opioid misuse and past-year suicidal ideation, suicide planning, and suicide attempts. Secondary data analyses were conducted using data from 41,053 participants of the 2014 National Survey of Drug Use and Health. Past-year frequency of prescription opioid misuse was grouped into 4 categories: none, less than monthly (1-11 times), monthly to weekly (12-51 times), and weekly or more (52 times or more). Binomial logistic regression analyses adjusted for demographics, overall health rating, depression, anxiety, and substance use disorders to test the associations between frequency of prescription opioid misuse and suicide-related variables. Compared to those who did not endorse prescription opioid misuse in the past year, prescription opioid misuse was significantly associated with suicidal ideation, suicide planning, and suicide attempts for each frequency of use category in unadjusted models (p < 0.05). In adjusted models, frequency of prescription opioid misuse remained significantly associated with suicidal ideation (p < 0.05 for each frequency category); however, only the group reporting weekly or more use on average was associated with suicide planning and attempts (p < 0.05). The findings provide novel specificity regarding prescription opioid use in relation to suicide-related outcomes further supporting enhanced access to suicide prevention and nonpharmacological approaches to pain management across various settings.
本研究旨在探讨过去一年中处方类阿片类药物滥用的频率与过去一年中自杀意念、自杀计划和自杀未遂之间的关系。本研究对来自 2014 年全国药物使用与健康调查的 41053 名参与者的二级数据进行了分析。过去一年中处方类阿片类药物滥用的频率被分为 4 个类别：无、每月少于 1 次（1-11 次）、每月至每周 1 次（12-51 次）和每周或更多次（52 次或更多次）。使用二项逻辑回归分析调整了人口统计学、总体健康状况评分、抑郁、焦虑和物质使用障碍等因素，以检验处方类阿片类药物滥用的频率与自杀相关变量之间的关联。与过去一年中未报告处方类阿片类药物滥用的人相比，在未经调整的模型中，每种使用频率类别均与自杀意念、自杀计划和自杀未遂显著相关（p<0.05）。在调整后的模型中，处方类阿片类药物滥用的频率仍与自杀意念显著相关（每个频率类别 p<0.05）；然而，只有报告每周或更多次使用的组平均与自杀计划和自杀未遂相关（p<0.05）。这些发现提供了与自杀相关结果有关的处方类阿片类药物使用的新颖特异性，进一步支持在各种环境中加强预防自杀和非药物方法来管理疼痛。
