肝移植后的胆汁淤积性肝病
Cholestatic Liver Diseases After Liver Transplant.
作者信息
Pena Polanco Nathalie A, Levy Cynthia, Martin Eric F
机构信息
Division of Internal Medicine, Miller School of Medicine, University of Miami, 1611 Northwest 12th Avenue, Suite Central 600-D, Miami, FL 33136, USA.
Division of Hepatology, Miller School of Medicine, University of Miami, 1120 Northwest 14th Street, Suite 1112, Miami, FL 33136, USA.
出版信息
Clin Liver Dis. 2017 May;21(2):403-420. doi: 10.1016/j.cld.2016.12.011.
Primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC) are the most common cholestatic liver diseases (CLD) in adults. Liver transplant (LT) is desirable for those who progress to end-stage liver disease. CLD have become an uncommon indication for LT. PSC and PBC accounted for 7.1% of all adult LT in 2015. CLD have the best post-LT outcomes compared with other indications for LT. Disease recurrence of PSC and PBC after LT is reported in up to 37% and 43% of LT recipients, respectively. Although recurrent PBC does not affect post-LT outcomes, recurrent PSC is associated with worse post-LT survival.
原发性硬化性胆管炎（PSC）和原发性胆汁性胆管炎（PBC）是成人中最常见的胆汁淤积性肝病（CLD）。对于进展至终末期肝病的患者，肝移植（LT）是理想的治疗方法。CLD已成为LT的一种不常见适应症。PSC和PBC在2015年占所有成人LT的7.1%。与LT的其他适应症相比，CLD的LT后预后最佳。据报道，LT受者中分别有高达37%和43%的人在LT后出现PSC和PBC疾病复发。虽然复发性PBC不影响LT后预后，但复发性PSC与LT后较差的生存率相关。
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