Nakajo M, Kobayashi H, Shimabukuro K, Shirono K, Sakata H, Taguchi M, Uchiyama N, Sonoda T, Shinohara S
Department of Radiology, Faculty of Medicine, Kagoshima University, Japan.
J Nucl Med. 1988 Jun;29(6):1066-77.
The biodistribution and in vivo kinetics of [131I]lipiodol infused into the hepatic artery were studied to estimate the potential of internal radiotherapy of hepatic cancer in five patients. It accumulated only in the vascular tumors and adjacent hepatic tissue (AHT) supplied by the infused artery, and to a lesser extent in the lung throughout 8 days imaging sequence. Iodine-131 lipiodol appeared to lead to oil embolization of the tumor and AHT followed by secondary embolization to the lungs and finally the activity was mainly excreted into urine. Four tumors had rapidly and slowly decreasing components, while the AHT activity decreased exponentially from the beginning. The effective half life in tumors was longer with the slow component (mean +/- s.d.: 5.7 +/- 1.2 days) than the AHT (3.7 +/- 0.6 days). The tumor/AHT concentration ratio in three patients at 2 hr was estimated to be 7.5-21. The activity was lower in the lungs than in the AHT in four patients. Iodine-131 lipiodol thus may be used as an intra-arterial infusion agent to treat certain vascular hepatic cancers.
对5例患者进行研究，以评估经肝动脉注入[131I]碘油的生物分布和体内动力学，从而估计其用于肝癌内放疗的潜力。在整个8天的成像过程中，它仅积聚在注入动脉所供应的血管性肿瘤及邻近肝组织（AHT）中，在肺中的积聚程度较低。碘-131碘油似乎导致肿瘤和AHT发生油栓塞，随后继发肺栓塞，最终放射性主要经尿液排出。4个肿瘤有快速和缓慢下降的成分，而AHT的放射性从一开始就呈指数下降。肿瘤中慢成分的有效半衰期（平均±标准差：5.7±1.2天）比AHT（3.7±0.6天）更长。3例患者在2小时时的肿瘤/AHT浓度比估计为7.5 - 21。4例患者肺中的放射性低于AHT。因此，碘-131碘油可作为动脉内灌注剂用于治疗某些血管性肝癌。
