Department of Neurology I.C., Sleep Research Centre, Oasi Institute for Research on Mental Retardation and Brain Aging (IRCCS), Troina, Italy.
Sleep and Epilepsy Center, Neurocenter of Southern Switzerland, Civic Hospital (EOC) of Lugano, Lugano, Switzerland.
Sleep Med. 2017 Apr;32:10-15. doi: 10.1016/j.sleep.2016.03.018. Epub 2016 Jun 7.
The aim of this study was to analyze statistically the number of single leg movements (LMs) forming bilateral LMs during sleep, along with their combined duration, to eventually provide evidence-based data for the adjustment of the current scoring rules defining bilateral LMs.
Polysomnographic recordings of 111 untreated patients with RLS with a median age of 56.0 years, along with 42 normal controls with a mean age of 60.0 years, were included. In each recording, we identified all LMs that were considered as bilateral when two or more LMs were overlapping or the onset of the following movement was <0.5 second after the offset of the preceding LM. The remaining LMs were classified as monolateral. A series of parameters were computed for both bilateral and monolateral LMs.
The duration of monolateral LMs in RLS patients was significantly longer than that of normal controls. For bilateral LMs, the maximum number of single LMs forming a bilateral movement and the maximum duration were slightly higher in RLS patients; however, the distribution of the number of individual LMs forming a single bilateral LM was similar. Only 0.12% and 0.27% of bilateral LMs consisted of >4 individual movements, and only 0.16% and 1.90% of bilateral LMs were >15 seconds in RLS patients and healthy controls, respectively.
Our results strongly suggest that bilateral LMs during sleep should be constituted by no more than four individual LMs and should have a maximum duration of 15 seconds.
本研究旨在统计睡眠中形成双侧腿部运动（LM）的单腿运动（LM）数量及其总时长，为当前定义双侧 LM 的评分规则的调整提供循证数据。
纳入 111 例未经治疗的 RLS 患者（中位年龄 56.0 岁）和 42 例正常对照者（平均年龄 60.0 岁）的多导睡眠图记录。在每个记录中，我们将所有被认为是双侧的 LM 识别出来，当两个或多个 LM 重叠或后续运动的起始时间距离前一个 LM 的结束时间<0.5 秒时，就将其视为双侧。其余的 LM 被归类为单侧。我们为双侧和单侧 LM 计算了一系列参数。
RLS 患者的单侧 LM 持续时间明显长于正常对照组。对于双侧 LM，RLS 患者中单次形成双侧运动的最大 LM 数量和最大持续时间略高；然而，形成单个双侧 LM 的单个 LM 数量的分布相似。只有 0.12%和 0.27%的双侧 LM 由>4 个单独的运动组成，只有 0.16%和 1.90%的双侧 LM 在 RLS 患者和健康对照组中分别超过 15 秒。
我们的结果强烈表明，睡眠中的双侧 LM 应由不超过四个单独的 LM 组成，并且持续时间不应超过 15 秒。
