Lloyd Rhodri O, O'Toole John M, Pavlidis Elena, Filan Peter M, Boylan Geraldine B
Neonatal Brain Research Group, Irish Centre for Fetal and Neonatal Translational Research (INFANT), Department of Pediatrics & Child Health, University College Cork, Cork, Ireland; Department of Neonatology, Cork University Maternity Hospital, Wilton, Cork, Ireland.
Neonatal Brain Research Group, Irish Centre for Fetal and Neonatal Translational Research (INFANT), Department of Pediatrics & Child Health, University College Cork, Cork, Ireland.
J Pediatr. 2017 Aug;187:18-25.e2. doi: 10.1016/j.jpeds.2017.03.004. Epub 2017 Mar 30.
To investigate the frequency and characteristics of electrographic seizures in preterm infants in the early postnatal period.
Infants <32 weeks gestational age (GA) (n = 120) were enrolled for continuous multichannel electroencephalography (EEG) recording initiated as soon as possible after birth and continued for approximately up to 72 hours of age. Electrographic seizures were identified visually, annotated, and analyzed. Quantitative descriptors of the temporal evolution of seizures, including total seizure burden, seizure duration, and maximum seizure burden, were calculated.
Median GA was 28.9 weeks (IQR, 26.6-30.3 weeks) and median birth weight was 1125 g (IQR, 848-1440 g). Six infants (5%; 95% CI, 1.9-10.6%) had electrographic seizures. Median total seizure burden, seizure duration, and maximum seizure burden were 40.3 minutes (IQR, 5.0-117.5 minutes), 49.6 seconds (IQR, 43.4-76.6 seconds), and 10.8 minutes/hour (IQR, 1.6-20.2 minutes/hour), respectively. Seizure burden was highest in 2 infants with significant abnormalities on neuroimaging.
Electrographic seizures are infrequent within the first few days of birth in very preterm infants. Seizures in this population are difficult to detect accurately without continuous multichannel EEG monitoring.
研究早产儿出生后早期脑电图癫痫发作的频率和特征。
纳入孕周<32周（GA）的婴儿（n = 120），出生后尽快开始进行连续多通道脑电图（EEG）记录，并持续至约72小时龄。通过肉眼识别、标注和分析脑电图癫痫发作。计算癫痫发作时间演变的定量描述指标，包括总癫痫发作负荷、发作持续时间和最大癫痫发作负荷。
中位孕周为28.9周（四分位间距，26.6 - 30.3周），中位出生体重为1125 g（四分位间距，848 - 1440 g）。6名婴儿（5%；95%可信区间，1.9 - 10.6%）出现脑电图癫痫发作。总癫痫发作负荷、发作持续时间和最大癫痫发作负荷的中位数分别为40.3分钟（四分位间距，5.0 - 117.5分钟）、49.6秒（四分位间距，43.4 - 76.6秒）和10.8分钟/小时（四分位间距，1.6 - 20.2分钟/小时）。2名神经影像学有明显异常的婴儿癫痫发作负荷最高。
极早产儿出生后头几天脑电图癫痫发作不常见。若无连续多通道脑电图监测，该人群的癫痫发作难以准确检测。
