Han Bo, Tokay Tursonjan, Zhang Guangming, Sun Peng, Hou Shangwei
Department of General Surgery, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China; Hongqiao International Institute of Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China.
Center for Life Sciences, National Laboratory Astana and School of Sciences and Technology, Nazarbayev University, Astana 010000, Kazakhstan.
Oxid Med Cell Longev. 2017;2017:7371010. doi: 10.1155/2017/7371010. Epub 2017 Mar 6.
1 (Eag1, Kv10.1, KCNH1) K channel is a member of the voltage-gated K channel family mainly distributed in the central nervous system and cancer cells. Like other types of voltage-gated K channels, the EAG1 channels are regulated by a variety of endogenous signals including reactive oxygen species, rendering the EAG1 to be in the redox-regulated ion channel family. The role of EAG1 channels in tumor development and its therapeutic significance have been well established. Meanwhile, the importance of hEAG1 channels in the nervous system is now increasingly appreciated. The present review will focus on the recent progress on the channel regulation by endogenous signals and the potential functions of EAG1 channels in normal neuronal signaling as well as neurological diseases.
1（Eag1、Kv10.1、KCNH1）钾通道是电压门控钾通道家族的成员，主要分布于中枢神经系统和癌细胞中。与其他类型的电压门控钾通道一样，EAG1通道受包括活性氧在内的多种内源性信号调节，这使得EAG1属于氧化还原调节离子通道家族。EAG1通道在肿瘤发生发展中的作用及其治疗意义已得到充分证实。与此同时，hEAG1通道在神经系统中的重要性也日益受到重视。本综述将聚焦于内源性信号对该通道调节的最新进展，以及EAG1通道在正常神经元信号传导和神经疾病中的潜在功能。
