组织工程化喉：在喉癌中的未来应用
Tissue-Engineered Larynx: Future Applications in Laryngeal Cancer.
作者信息
Hamilton Nick J I, Birchall Martin A
机构信息
University College London Ear Institute, Gray's Inn Road, London, UK.
出版信息
Curr Otorhinolaryngol Rep. 2017;5(1):42-48. doi: 10.1007/s40136-017-0144-6. Epub 2017 Mar 14.
PURPOSE OF REVIEW
This article reviews the latest developments in tissue engineering for the larynx with a specific focus on the treatment of laryngeal cancer.
RECENT FINDINGS
Challenges in tissue engineering a total larynx can be divided into scaffold design, methods of re-mucosalization, and how to restore laryngeal function. The literature described a range of methods to deliver a laryngeal scaffold including examples of synthetic, biomimetic, and biological scaffolds. Methods to regenerate laryngeal mucosa can be divided into examples that use a biological dressing and those that engineer a new mucosal layer de novo. Studies aiming to restore laryngeal function have been reported, but to date, the optimum method for achieving this as part of a total laryngeal transplant is yet to be determined.
SUMMARY
There is great potential for tissue engineering to improve the treatments available for laryngeal cancer within the next 10 years. A number of challenges exist however and advances in restoring function must keep pace with developments in scaffold design.
综述目的
本文回顾了喉组织工程的最新进展，特别关注喉癌的治疗。
最新发现
全喉组织工程面临的挑战可分为支架设计、重新黏膜化方法以及如何恢复喉功能。文献中描述了多种递送喉支架的方法，包括合成支架、仿生支架和生物支架的实例。喉黏膜再生方法可分为使用生物敷料的实例和从头构建新黏膜层的实例。已有旨在恢复喉功能的研究报道，但迄今为止，作为全喉移植一部分实现这一目标的最佳方法尚未确定。
总结
未来10年内，组织工程在改善喉癌治疗方法方面具有巨大潜力。然而，仍存在一些挑战，功能恢复方面的进展必须与支架设计的发展同步。
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