Thai Thanh Truc, Jones Mairwen K, Harris Lynne M, Heard Robert C
1 Faculty of Public Health, Ho Chi Minh City University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam.
2 Behavioral and Social Sciences in Health, Faculty of Health Sciences, University of Sydney, Sydney, Australia.
J Int Assoc Provid AIDS Care. 2017 Jul/Aug;16(4):366-375. doi: 10.1177/2325957417701195. Epub 2017 Apr 3.
This study identified prevalence and correlates of HIV-associated dementia (HAD) among people living with HIV (PLWHA) in Ho Chi Minh City, Vietnam. Four hundred PLWHA completed a self-report questionnaire and were interviewed by a trained researcher to assess HAD using the International HIV Dementia Scale (IHDS). Clinical information concerning HIV treatment was also extracted from medical records. The results indicate the prevalence of probable HAD based on IHDS score <10.5 was 39.8% (95% confidence interval [CI]: 35.0%-44.5%). Probable HAD was significantly higher among female, older PLWHA and among those with low education level (≤ primary school), moderate level of adherence to HIV medication and HIV stage 3. Those PLWHA with depressive symptoms also had higher odds of having probable HAD (odds ratio = 3.23, 95% CI: 2.05-5.11). These findings underscore the importance of early HAD screening and appropriate referral for further assessment and management of PLWHA especially those with higher risk of HAD.
本研究确定了越南胡志明市艾滋病毒感染者(PLWHA)中与艾滋病毒相关的痴呆症(HAD)的患病率及其相关因素。400名艾滋病毒感染者完成了一份自我报告问卷,并由一名经过培训的研究人员进行访谈,以使用国际艾滋病毒痴呆量表(IHDS)评估HAD。还从医疗记录中提取了有关艾滋病毒治疗的临床信息。结果表明,基于IHDS评分<10.5的可能患有HAD的患病率为39.8%(95%置信区间[CI]:35.0%-44.5%)。在女性、年龄较大的艾滋病毒感染者以及教育水平较低(≤小学)、艾滋病毒药物依从性中等和处于艾滋病毒3期的人群中,可能患有HAD的比例显著更高。那些有抑郁症状的艾滋病毒感染者也更有可能患有可能的HAD(优势比=3.23,95%CI:2.05-5.11)。这些发现强调了对艾滋病毒感染者,尤其是那些患HAD风险较高的感染者进行早期HAD筛查以及适当转诊以进行进一步评估和管理的重要性。