Peng Ting, Lin Hui, Liu Qinglin, Yang Jiajin, Cao Wei, Ding Hui, Tang Lingli
Department of Laboratory Medicine, Second Xiangya Hospital, Central South University.
Department of Obstetrics and Gynecology, Second Xiangya Hospital, Central South University.
Jpn J Infect Dis. 2017 Sep 25;70(5):518-521. doi: 10.7883/yoken.JJID.2016.522. Epub 2017 Mar 28.
A total of 1,294 Neisseria gonorrhoeae isolates obtained in Changsha, China from 2003 to 2015 were examined for their susceptibility to penicillin (PEN), ciprofloxacin (CIP), spectinomycin (SPT), and ceftriaxone (CRO) using the disc diffusion method. In addition, the minimum inhibitory concentrations (MICs) of CRO for 460 isolates collected during 2008-2015 was determined by agar dilution method. Isolates with intermediate CRO susceptibility were additionally tested for azithromycin susceptibility. Results demonstrated that the rate of resistance to PEN and CIP were 77.5 % and 94.2 %, respectively. Only 4 SPT-resistant and 2 SPT-intermediate isolates were identified. No CRO-resistant isolates were identified, although the percentage with intermediate susceptibility increased from 1.8% in 2012 to 11.9% in 2015. Among these, 3 isolates showed no susceptibility to azithromycin with 2 isolates showing an MIC of 0.5 μg/mL and 1 isolate showing an MIC of 1.0 μg/mL. We recommend azithromycin for treating strains that demonstrate intermediate susceptible to CRO and azithromycin-susceptible N. gonorrhoeae isolates occurring in Changsha.
采用纸片扩散法对2003年至2015年在中国长沙分离得到的1294株淋病奈瑟菌进行了青霉素（PEN）、环丙沙星（CIP）、壮观霉素（SPT）和头孢曲松（CRO）敏感性检测。此外，采用琼脂稀释法测定了2008 - 2015年期间收集的460株菌株对CRO的最低抑菌浓度（MIC）。对CRO敏感性为中介的菌株还进行了阿奇霉素敏感性检测。结果显示，对PEN和CIP的耐药率分别为77.5%和94.2%。仅鉴定出4株对SPT耐药和2株对SPT敏感性为中介的菌株。未鉴定出对CRO耐药的菌株，不过敏感性为中介的百分比从2012年的1.8%增至2015年的11.9%。其中，3株对阿奇霉素不敏感，2株MIC为0.5μg/mL，1株MIC为1.0μg/mL。我们建议使用阿奇霉素治疗在长沙出现的对CRO敏感性为中介的菌株以及对阿奇霉素敏感的淋病奈瑟菌分离株。
