Asad Maaz, Abdul Aziz Alwani W, Raman Renukanth P C, Harun Himratul-Aznita W, Ali Tara Bai T, Chinna Karuthan, Vaithilingam Rathna D
Department of Restorative Dentistry, Faculty of Dentistry, University of Malaya.
J Oral Sci. 2017;59(1):111-120. doi: 10.2334/josnusd.16-0298.
We evaluated changes in clinical variables and microbiological profiles of periodontopathogens among 56 patients with moderate to severe CP who were randomly assigned to oral hygiene instruction (OHI; n = 28) or nonsurgical periodontal treatment (NSPT; n = 28). Periodontal variables were assessed and subgingival plaque samples were obtained from deep pockets (≥5 mm) at baseline and 3 months after treatment. Real-time polymerase chain reaction was used to quantify Actinobacillus actinomycetemcomitans, Tannerella forsythia, Porphyromonas gingivalis, and Prevotella intermedia. All clinical variables significantly improved in both groups. Improvements in gingival bleeding index (GBI), probing pocket depth (PPD), and periodontal attachment loss (PAL) were significantly greater at 3 months after treatment in the NSPT group. At baseline, the prevalences of all pathogens were high. Significant reductions in microbial count were observed for A. actinomycetemcomitans and T. forsythia (P ≤ 0.05) in the NSPT group. None of the improvements in clinical variables was associated with changes in microbiological profiles. At 3 months after treatment, NSPT was associated with significantly greater improvements in GBI, PPD, and PAL as compared with OHI. A. actinomycetemcomitans and T. forsythia counts were significantly lower in the NSPT group.
我们评估了56例中重度慢性牙周炎患者的临床变量和牙周病原体微生物学特征的变化，这些患者被随机分配至口腔卫生指导组（OHI；n = 28）或非手术牙周治疗组（NSPT；n = 28）。在基线和治疗后3个月评估牙周变量，并从深牙周袋（≥5 mm）获取龈下菌斑样本。采用实时聚合酶链反应定量检测伴放线放线杆菌、福赛坦纳菌、牙龈卟啉单胞菌和中间普氏菌。两组的所有临床变量均显著改善。治疗后3个月，NSPT组的牙龈出血指数（GBI）、探诊深度（PPD）和牙周附着丧失（PAL）的改善程度显著更大。基线时，所有病原体的患病率都很高。NSPT组中伴放线放线杆菌和福赛坦纳菌的微生物计数显著降低（P≤0.05）。临床变量的改善均与微生物学特征的变化无关。治疗后3个月，与OHI相比，NSPT组在GBI、PPD和PAL方面的改善显著更大。NSPT组中伴放线放线杆菌和福赛坦纳菌的计数显著更低。
