核受体家族的成熟
Maturing of the nuclear receptor family.
作者信息
Lazar Mitchell A
出版信息
J Clin Invest. 2017 Apr 3;127(4):1123-1125. doi: 10.1172/JCI92949.
Abstract
Members of the nuclear receptor (NR) superfamily of ligand-regulated transcription factors play important roles in reproduction, development, and physiology. In humans, genetic mutations in NRs are causes of rare diseases, while hormones and drugs that target NRs are in widespread therapeutic use. The present issue of the JCI includes a series of Review articles focused on specific NRs and their wide range of biological functions. Here I reflect on the past, present, and potential future highlights of research on the NR superfamily.
摘要
核受体（NR）超家族的配体调节转录因子成员在生殖、发育和生理过程中发挥着重要作用。在人类中，核受体的基因突变是罕见疾病的病因，而靶向核受体的激素和药物在广泛的治疗中使用。本期《临床研究杂志》（JCI）刊载了一系列综述文章，聚焦于特定的核受体及其广泛的生物学功能。在此，我回顾核受体超家族研究的过去、现在及潜在的未来亮点。
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