Gory Benjamin, Aguilar-Pérez Marta, Pomero Elisa, Turjman Francis, Weber Werner, Fischer Sebastian, Henkes Hans, Biondi Alessandra
FHU IRIS, Department of Interventional Neuroradiology, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon, France.
Department of Neuroradiology, Klinikum Stuttgart, Stuttgart, Germany.
Neurosurgery. 2017 Jun 1;80(6):925-933. doi: 10.1093/neuros/nyw131.
Bifurcation middle cerebral artery (MCA) aneurysms with wide neck are amenable to endovascular coiling with pCONus stent, a recent device dedicated to wide-neck bifurcation intracranial aneurysms.
To evaluate the 1-year angiographic follow-up of wide-neck MCA aneurysms treated with pCONus.
Forty MCA aneurysms (mean dome size, 7.7 mm; mean neck size, 5.6 mm) coiled with pCONus were retrospectively evaluated. "Recanalization" was defined as worsening, and "progressive thrombosis" was defined as improvement on the Raymond scale.
Angiographic midterm (mean, 11.9 months; range, 3-20) follow-up was obtained in all aneurysms. Retreatment was performed in 9 aneurysms (22.5%) without clinical complications, and postoperative angiographic outcome included 2 complete occlusions and 7 neck remnants. Six aneurysms were followed after retreatment (mean, 8.8 months), and presented complete occlusion in 1 case, neck remnant in 4 cases, and aneurysm remnant in 1 case. Among the 31 aneurysms, follow-up showed complete occlusion in 67.7% (21/31), neck remnants in 29% (9/31), and aneurysm remnants in 3.3% (1/31). Adequate aneurysm occlusion (total occlusion and neck remnant) was obtained in 96.7% (30/31). Among these 31 aneurysms, improvement of the rate of occlusion was observed in 15 aneurysms (48.4%), and recurrence in 2 aneurysms (6.5%). There was no 1-year angiographic recurrence of 3- or 6-month totally occluded aneurysms.
pCONus stent allows a safe coiling of wide-neck MCA aneurysms usually considered as surgical with a low recanalization rate for those adequately occluded at 3 to 6 months. Angiographic results improve over time due to progressive aneurysm thrombosis in around 50% of cases.
宽颈大脑中动脉(MCA)分叉部动脉瘤适合采用pCONus支架进行血管内栓塞治疗,pCONus是一种专门用于治疗宽颈颅内分叉部动脉瘤的新型装置。
评估采用pCONus治疗宽颈MCA动脉瘤的1年血管造影随访结果。
回顾性评估40例采用pCONus进行栓塞治疗的MCA动脉瘤(平均瘤顶大小为7.7mm;平均瘤颈大小为5.6mm)。“再通”定义为病情恶化,“血栓进展”定义为根据雷蒙德分级病情改善。
所有动脉瘤均获得了血管造影中期(平均11.9个月;范围3 - 20个月)随访。9例动脉瘤(22.5%)进行了再次治疗,无临床并发症,术后血管造影结果包括2例完全闭塞和7例瘤颈残留。6例动脉瘤再次治疗后进行了随访(平均8.8个月),其中1例完全闭塞,4例瘤颈残留,1例动脉瘤残留。在31例动脉瘤中,随访显示67.7%(21/31)完全闭塞,29%(9/31)瘤颈残留,3.3%(1/31)动脉瘤残留。96.7%(30/31)的动脉瘤实现了充分闭塞(完全闭塞和瘤颈残留)。在这31例动脉瘤中,15例(48.4%)观察到闭塞率改善,2例(6.5%)复发。3个月或6个月时完全闭塞的动脉瘤在1年时无血管造影复发。
pCONus支架能够安全地栓塞通常被认为需手术治疗的宽颈MCA动脉瘤,对于在3至6个月时充分闭塞的动脉瘤,再通率较低。约50%的病例中,由于动脉瘤内血栓逐渐形成,血管造影结果随时间推移有所改善。