Zhou Lixia, Wu Yueming, Guo Yang, Li Yanjun, Li Na, Yang Yi, Qin Xueyun
a Third Affiliated Hospital , Liaoning Medical College , Jinzhou , China.
b First Affiliated Hospital , Jinzhou Medical University , Fuzhou , China.
Cancer Invest. 2017 May 28;35(5):289-300. doi: 10.1080/07357907.2016.1278226. Epub 2017 Apr 3.
Although diagnosis and treatment of gastric cancer have improved, the prognosis of patients remains poor. The majority of patients should be treated with chemotherapy or other follow-up treatment. However, the drug resistance of chemotherapy and heterogeneity of tumor itself lead to differences of sensitivity of chemotherapy drugs for different patients. Therefore, it is mandatory to develop better methods of treatment for treatment of gastric cancer. Calycosin has been used in several types of cancer cells. Cisplatin, 5-fluorouracil (5-FU), and adriamycin (ADM) are most widely used drugs for chemotherapy, and they improve the overall survival of cancer patients. To study whether and how calycosin enhances their inhibition of gastric cancer cells, we detected the signaling pathway in which calycosin and cisplatin, 5-FU, and ADM play role in human gastric cells lines. We found that calycosin can enhance the suppression of cisplatin to gastric cell line by inhibiting the phosphorylation of protein kinase B (Akt). So, when cisplatin/5-FU/ADM is combined with calycosin, it can achieve better therapeutic effect in lower concentration.
尽管胃癌的诊断和治疗已有改善，但患者的预后仍然很差。大多数患者应接受化疗或其他后续治疗。然而，化疗的耐药性和肿瘤本身的异质性导致不同患者对化疗药物的敏感性存在差异。因此，必须开发更好的胃癌治疗方法。毛蕊异黄酮已用于多种癌细胞。顺铂、5-氟尿嘧啶（5-FU）和阿霉素（ADM）是最广泛使用的化疗药物，它们提高了癌症患者的总体生存率。为了研究毛蕊异黄酮是否以及如何增强它们对胃癌细胞的抑制作用，我们检测了毛蕊异黄酮和顺铂、5-FU以及ADM在人胃癌细胞系中发挥作用的信号通路。我们发现毛蕊异黄酮可以通过抑制蛋白激酶B（Akt）的磷酸化来增强顺铂对胃癌细胞系的抑制作用。所以，当顺铂/5-FU/ADM与毛蕊异黄酮联合使用时，在较低浓度下就能取得更好的治疗效果。
