从亚得里亚海中部沿海水域（意大利马尔凯地区）采集的加利福尼亚贻贝生物标志物的转录变异。
Transcriptional variations in biomarkers of Mytilus galloprovincialis sampled from Central Adriatic coastal waters (Marche region, Italy).
作者信息
Cocci Paolo, Capriotti Martina, Mosconi Gilberto, Palermo Francesco Alessandro
机构信息
a School of Biosciences and Veterinary Medicine, University of Camerino , Camerino , Italy.
出版信息
Biomarkers. 2017 Sep;22(6):537-547. doi: 10.1080/1354750X.2017.1315614. Epub 2017 Apr 19.
OBJECTIVE
this work evaluates the expression of several biomarker genes (i.e. CAT, HSPs, MT10, p53, GSTpi, ER1/2) in Mytilus galloprovincialis native specimens to identify pollution related transcriptional changes.
METHODS
gene expression levels were analysed in the gills of mussels from five sites along a coastal area of the central Adriatic Sea, using qPCR.
RESULTS
we observed higher expression levels of biomarker genes in mussels from the local harbour or river mouths than in mussels from the reference site and offshore platform.
CONCLUSIONS
the variations in gene expression observed indicated high sensitivity to pollutants, and showed differences among the sampling sites.
目的
本研究评估了几种生物标志物基因（即CAT、热休克蛋白、MT10、p53、GSTpi、ER1/2）在本地种加利福尼亚贻贝中的表达，以确定与污染相关的转录变化。
方法
使用qPCR分析了亚得里亚海中部沿海地区五个地点的贻贝鳃中的基因表达水平。
结果
我们观察到，来自当地港口或河口的贻贝中生物标志物基因的表达水平高于来自参考地点和近海平台的贻贝。
结论
观察到的基因表达变化表明对污染物高度敏感，并且在采样地点之间存在差异。
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