From the College of Pharmacy, Pusan National University, Busan, South Korea.
J Patient Saf. 2019 Dec;15(4):e56-e59. doi: 10.1097/PTS.0000000000000373.
The aim of the study was to explore the current status of drug-induced parkinsonism and drugs possibly related to drug-induced parkinsonism in Korea.
We conducted a cross-sectional study using the Korea Adverse Event Reporting System database between July 1, 2010, and June 30, 2015. We identified all adverse event reports associated with parkinsonism.
There were 1402 adverse event reports associated with parkinsonism. The number of adverse event reports has increased annually. Among the 1499 drugs associated with parkinsonism, the most common were metoclopramide (49.77%) and paliperidone (16.14%). The major therapeutic groups (the third level of the Anatomical Therapeutic Chemical code) were propulsives (53.87%) and antipsychotics (35.58%). The mean time of onset of parkinsonism was 34.9 days. However, the time of onset of parkinsonism varied by drug, for example, it was 4.6 days for metoclopramide and 37.2 days for paliperidone.
Metoclopramide and antipsychotics were reported in most adverse event reports associated with parkinsonism in Korea.
本研究旨在探讨韩国药物性帕金森病的现状及可能与药物性帕金森病相关的药物。
我们使用韩国不良事件报告系统数据库进行了一项横断面研究，时间为 2010 年 7 月 1 日至 2015 年 6 月 30 日。我们确定了所有与帕金森病相关的不良事件报告。
共有 1402 份与帕金森病相关的不良事件报告。不良事件报告数量逐年增加。在与帕金森病相关的 1499 种药物中，最常见的是甲氧氯普胺（49.77%）和帕利哌酮（16.14%）。主要治疗组（解剖治疗化学分类的第三级）为推进剂（53.87%）和抗精神病药（35.58%）。帕金森病的发病平均时间为 34.9 天。然而，帕金森病的发病时间因药物而异，例如甲氧氯普胺为 4.6 天，帕利哌酮为 37.2 天。
在韩国与帕金森病相关的不良事件报告中，甲氧氯普胺和抗精神病药报告最多。
