Department of Dermatology, Dokkyo Medical University, School of Medicine, Mibu, Tochigi, Japan.
Int J Dermatol. 2017 Aug;56(8):889-893. doi: 10.1111/ijd.13608. Epub 2017 Mar 30.
The use of potassium iodide (KI) to treat palmoplantar pustulosis (PPP) and pustulotic arthro-osteitis (PAO) has not previously been reported. Here, we report the first successful treatment of PPP and PAO with KI.
Among 25 patients with PPP, seven had an associated PAO. All patients were administered 900 mg KI three times per day for 3 months. Overall, 12 patients received this medical treatment for the first time or had >6 months interval since the last therapy for PPP. The other 13 patients who were nonresponsive to tetracycline for >3 months prior to KI treatment were treated with a combination of KI and tetracycline. All seven patients with PAO were included in the tetracycline and KI-treated group.
More than 70% of patients demonstrated complete clearance or ≥50% improvement in palmoplantar pustular psoriasis area and severity index (PPPASI) from baseline. In the group with <50% improvement in PPPASI from baseline, all except one patient were smokers. In the KI with tetracycline treatment group, approximately 80% demonstrated improvement. At the end of 3 months, there was remission of arthralgia in five out of seven PPP patients with PAO.
Treatment with KI and/or its combination with tetracycline may be a useful treatment for PPP/PAO. Smoking may affect the effectiveness of these treatment modalities.
碘化钾（KI）用于治疗掌跖脓疱病（PPP）和脓疱性关节炎-骨炎（PAO）此前尚未有报道。在此，我们报告首例 KI 成功治疗 PPP 和 PAO。
在 25 例 PPP 患者中，有 7 例合并有 PAO。所有患者均每天服用 900mgKI，分 3 次服用，持续 3 个月。总体而言，12 例患者为首次接受该治疗或 PPP 上次治疗后>6 个月。在开始 KI 治疗前>3 个月对四环素无反应的 13 例患者，采用 KI 和四环素联合治疗。7 例 PAO 患者均纳入四环素和 KI 治疗组。
70%的患者在掌跖脓疱病面积和严重指数（PPPASI）上从基线完全清除或改善≥50%。在 PPPASI 较基线改善<50%的组中，除 1 例患者外均为吸烟者。在 KI 加四环素治疗组中，约 80%的患者得到改善。在 3 个月结束时，7 例合并 PAO 的 PPP 患者中有 5 例关节痛缓解。
KI 治疗及其与四环素的联合治疗可能是 PPP/PAO 的有效治疗方法。吸烟可能会影响这些治疗方法的有效性。
